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Year Number of Results
1829 1
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1868 1
1872 1
1881 1
1885 1
1890 1
1893 1
1895 4
1896 1
1897 2
1898 2
1899 2
1900 4
1901 2
1903 2
1906 3
1908 1
1910 1
1911 1
1912 2
1913 4
1918 1
1924 1
1925 4
1926 3
1927 2
1929 1
1931 1
1933 2
1934 1
1935 1
1936 3
1937 2
1938 3
1939 3
1940 1
1942 2
1943 2
1944 1
1945 2
1946 15
1947 17
1948 18
1949 4
1950 11
1951 22
1952 12
1953 14
1954 21
1955 12
1956 18
1957 30
1958 18
1959 13
1960 15
1961 14
1962 18
1963 24
1964 35
1965 12
1966 23
1967 30
1968 45
1969 50
1970 61
1971 63
1972 64
1973 60
1974 58
1975 60
1976 55
1977 53
1978 56
1979 73
1980 81
1981 75
1982 78
1983 83
1984 108
1985 92
1986 121
1987 138
1988 127
1989 135
1990 148
1991 131
1992 163
1993 184
1994 203
1995 157
1996 175
1997 184
1998 190
1999 190
2000 198
2001 191
2002 194
2003 199
2004 257
2005 285
2006 311
2007 311
2008 360
2009 344
2010 351
2011 388
2012 386
2013 498
2014 467
2015 467
2016 457
2017 427
2018 490
2019 464
2020 582
2021 655
2022 579
2023 546
2024 234

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12,419 results

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Page 1
Kemp Eliminase Activity of Ketosteroid Isomerase.
Lamba V, Sanchez E, Fanning LR, Howe K, Alvarez MA, Herschlag D, Forconi M. Lamba V, et al. Biochemistry. 2017 Jan 31;56(4):582-591. doi: 10.1021/acs.biochem.6b00762. Epub 2017 Jan 20. Biochemistry. 2017. PMID: 28045505 Free PMC article.
Nevertheless, several other systems such as micelles, catalytic antibodies, and cavitands are known to accelerate the Kemp elimination by several orders of magnitude. We found that the naturally occurring enzyme ketosteroid isomerase (KSI) also catalyzes the Kemp el …
Nevertheless, several other systems such as micelles, catalytic antibodies, and cavitands are known to accelerate the Kemp eliminatio …
Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity.
Caselle EA, Yoon JH, Bhattacharya S, Rempillo JJL, Lengyel Z, D'Souza A, Moroz YS, Tolbert PL, Volkov AN, Forconi M, Castañeda CA, Makhlynets OV, Korendovych IV. Caselle EA, et al. ChemCatChem. 2019 Mar 6;11(5):1425-1430. doi: 10.1002/cctc.201801994. Epub 2019 Jan 15. ChemCatChem. 2019. PMID: 31788134 Free PMC article.
Minimalist enzymes designed to catalyze model reactions provide useful starting points for creating catalysts for practically important chemical transformations. We have shown that Kemp eliminases of the AlleyCat family facilitate conversion of leflunomide (an immunosupres …
Minimalist enzymes designed to catalyze model reactions provide useful starting points for creating catalysts for practically important chem …
Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme.
Gutierrez-Rus LI, Alcalde M, Risso VA, Sanchez-Ruiz JM. Gutierrez-Rus LI, et al. Int J Mol Sci. 2022 Aug 11;23(16):8934. doi: 10.3390/ijms23168934. Int J Mol Sci. 2022. PMID: 36012203 Free PMC article.
Here, we present an engineered ancestral beta-lactamase with a new active site that is capable of efficiently catalyzing Kemp elimination. The engineering of our Kemp eliminase involved minimalist design based on a single function-generating mutation, inclusion of a …
Here, we present an engineered ancestral beta-lactamase with a new active site that is capable of efficiently catalyzing Kemp elimina …
Kemp Elimination Catalyzed by Naturally Occurring Aldoxime Dehydratases.
Miao Y, Metzner R, Asano Y. Miao Y, et al. Chembiochem. 2017 Mar 2;18(5):451-454. doi: 10.1002/cbic.201600596. Epub 2017 Jan 25. Chembiochem. 2017. PMID: 28120515
In contrast to in silico enzyme design, we were interested in searching for Kemp eliminase activity in natural enzymes with catalytic promiscuity. ...Although a few natural enzymes have been identified with promiscuous Kemp eliminase activity, to the best of our kno …
In contrast to in silico enzyme design, we were interested in searching for Kemp eliminase activity in natural enzymes with catalytic …
Structural characterization and Kemp eliminase activity of the Mycobacterium smegmatis Ketosteroid Isomerase.
Liang Y, Li W, Liang H, Lou X, Liu R, Zhang Q, Bartlam M. Liang Y, et al. Biochem Biophys Res Commun. 2021 Jun 30;560:159-164. doi: 10.1016/j.bbrc.2021.05.007. Epub 2021 May 13. Biochem Biophys Res Commun. 2021. PMID: 33992958
The Kemp elimination reaction, involving the ring-opening of benzoxazole and its derivatives under the action of natural enzymes or chemical catalysts, has been of interest to researchers since its discovery. Because this reaction does not exist in all currently known meta …
The Kemp elimination reaction, involving the ring-opening of benzoxazole and its derivatives under the action of natural enzymes or c …
Convergence in determining enzyme functional descriptors across Kemp eliminase variants.
Jiang Y, Stull SL, Shao Q, Yang ZJ. Jiang Y, et al. Electron Struct. 2022 Dec;4(4):044007. doi: 10.1088/2516-1075/acad51. Epub 2022 Dec 30. Electron Struct. 2022. PMID: 37425623 Free PMC article.
Here, we conducted convergence tests for dynamics-derived and electrostatic descriptors on 18 Kemp eliminase variants across six active-site regions with various boundary distances to the substrate. ...To understand the effects of electronic structure, the EF was also eval …
Here, we conducted convergence tests for dynamics-derived and electrostatic descriptors on 18 Kemp eliminase variants across six acti …
Syndrome X revisited.
Kemp HG Jr. Kemp HG Jr. J Am Coll Cardiol. 1991 Feb;17(2):507-8. doi: 10.1016/s0735-1097(10)80123-8. J Am Coll Cardiol. 1991. PMID: 1991910 Free article. No abstract available.
A preorganization oriented computational method for de novo design of Kemp elimination enzymes.
Zhang S, Zhang J, Luo W, Wang P, Zhu Y. Zhang S, et al. Enzyme Microb Technol. 2022 Oct;160:110093. doi: 10.1016/j.enzmictec.2022.110093. Epub 2022 Jul 2. Enzyme Microb Technol. 2022. PMID: 35816919
A preorganization oriented computational strategy for de novo enzyme design based on computational enzyme design tool PRODA was developed and demonstrated by the creation of Kemp elimination enzymes. A pre-organized active site model of proton transfer from carbon with a l …
A preorganization oriented computational strategy for de novo enzyme design based on computational enzyme design tool PRODA was developed an …
Kemp Elimination in Cationic Micelles: Designed Enzyme-Like Rates Achieved through the Addition of Long-Chain Bases.
Sanchez E, Lu S, Reed C, Schmidt J, Forconi M. Sanchez E, et al. J Phys Org Chem. 2016 Apr;29(4):185-189. doi: 10.1002/poc.3515. Epub 2015 Dec 1. J Phys Org Chem. 2016. PMID: 27162418 Free PMC article.
The Kemp elimination is prototypical reaction used to study proton abstraction from carbon. ...Because natural enzymes use specific interactions to position their substrates, we propose that acceleration of the Kemp elimination is not a suitable benchmark for the su …
The Kemp elimination is prototypical reaction used to study proton abstraction from carbon. ...Because natural enzymes use specific i …
12,419 results
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