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584 results

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A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway.
Elsasser S, Elia LP, Morimoto RI, Powers ET, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Finkbeiner S, Gestwicki JE, Richardson RAK, Stoeger T, Tan EP, Xiao Q, Cole CM, Massey LA, Garza D, Kelly JW, Rainbolt TK, Chou CC, Masto VB, Frydman J, Nixon RA. Elsasser S, et al. Among authors: kelly jw. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533675. doi: 10.1101/2023.03.22.533675. bioRxiv. 2023. PMID: 36993380 Free PMC article. Preprint.
Proteostasis and lysosomal quality control deficits in Alzheimer's disease neurons.
Chou CC, Vest R, Prado MA, Wilson-Grady J, Paulo JA, Shibuya Y, Moran-Losada P, Lee TT, Luo J, Gygi SP, Kelly JW, Finley D, Wernig M, Wyss-Coray T, Frydman J. Chou CC, et al. Among authors: kelly jw. bioRxiv [Preprint]. 2023 Mar 27:2023.03.27.534444. doi: 10.1101/2023.03.27.534444. bioRxiv. 2023. PMID: 37034684 Free PMC article. Preprint.
Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease.
Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips JL, Iturbe A, Erqiuzi A, Moore BD, Ryu D, Natu A, Dillon KD, Torrellas J, Moran C, Ladd TB, Afroz KF, Islam T, Jagirdar J, Funk CC, Robinson M, Borchelt DR, Ertekin-Taner N, Kelly JW, Heppner FL, Johnson EC, McFarland K, Levey AL, Prokop S, Seyfried NT, Golde TE. Levites Y, et al. Among authors: kelly jw. bioRxiv [Preprint]. 2023 Dec 7:2023.11.29.568318. doi: 10.1101/2023.11.29.568318. bioRxiv. 2023. PMID: 38076912 Free PMC article. Preprint.
Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B.
Touvier T, Veneri FA, Claessens A, Ferri C, Mastrangelo R, Sorgiati N, Bianchi F, Valenzano S, Del Carro U, Rivellini C, Duong P, Shy ME, Kelly JW, Svaren J, Wiseman RL, D'Antonio M. Touvier T, et al. Among authors: kelly jw. bioRxiv [Preprint]. 2024 Feb 2:2024.01.31.577760. doi: 10.1101/2024.01.31.577760. bioRxiv. 2024. PMID: 38352425 Free PMC article. Preprint.
The conformational landscape of human transthyretin revealed by cryo-EM.
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC. Basanta B, et al. Among authors: kelly jw. bioRxiv [Preprint]. 2024 Jan 23:2024.01.23.576879. doi: 10.1101/2024.01.23.576879. bioRxiv. 2024. PMID: 38328110 Free PMC article. Preprint.
Biochemistry and Protein Interactions of the CYREN Microprotein.
Xie L, Bowman ME, Louie GV, Zhang C, Ardejani MS, Huang X, Chu Q, Donaldson CJ, Vaughan JM, Shan H, Powers ET, Kelly JW, Lyumkis D, Noel JP, Saghatelian A. Xie L, et al. Among authors: kelly jw. Biochemistry. 2023 Nov 7;62(21):3050-3060. doi: 10.1021/acs.biochem.3c00397. Epub 2023 Oct 9. Biochemistry. 2023. PMID: 37813856
Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.
Kline GM, Paxman RJ, Lin CY, Madrazo N, Yoon L, Grandjean JMD, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Kline GM, et al. Among authors: kelly jw. ACS Chem Biol. 2023 Aug 18;18(8):1719-1729. doi: 10.1021/acschembio.3c00042. Epub 2023 Jul 31. ACS Chem Biol. 2023. PMID: 37523656 Free PMC article.
584 results