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Resistance to antifungals that target CYP51.
Parker JE, Warrilow AG, Price CL, Mullins JG, Kelly DE, Kelly SL. Parker JE, et al. Among authors: kelly de, kelly sl. J Chem Biol. 2014 Aug 27;7(4):143-61. doi: 10.1007/s12154-014-0121-1. eCollection 2014 Oct. J Chem Biol. 2014. PMID: 25320648 Free PMC article. Review.
A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.
Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL. Martel CM, et al. Among authors: kelly de, kelly sl. Antimicrob Agents Chemother. 2010 Sep;54(9):3578-83. doi: 10.1128/AAC.00303-10. Epub 2010 Jun 14. Antimicrob Agents Chemother. 2010. PMID: 20547793 Free PMC article.
Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).
Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL. Warrilow AG, et al. Among authors: kelly de, kelly sl. Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. doi: 10.1128/AAC.00587-10. Epub 2010 Jul 12. Antimicrob Agents Chemother. 2010. PMID: 20625155 Free PMC article.
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.
Martel CM, Parker JE, Warrilow AG, Rolley NJ, Kelly SL, Kelly DE. Martel CM, et al. Among authors: kelly de, kelly sl. Antimicrob Agents Chemother. 2010 Nov;54(11):4920-3. doi: 10.1128/AAC.00349-10. Epub 2010 Aug 23. Antimicrob Agents Chemother. 2010. PMID: 20733045 Free PMC article.
177 results