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Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer. 2021 Oct;2(10):1002-1017. Epub 2021 Sep 27.
Nat Cancer. 2021.
PMID: 34790902
Free PMC article.
Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.
Gerhart SV, Kellner WA, Thompson C, Pappalardi MB, Zhang XP, Montes de Oca R, Penebre E, Duncan K, Boriack-Sjodin A, Le B, Majer C, McCabe MT, Carpenter C, Johnson N, Kruger RG, Barbash O.
Gerhart SV, et al. Among authors: kellner wa.
Sci Rep. 2018 Jun 26;8(1):9711. doi: 10.1038/s41598-018-28002-y.
Sci Rep. 2018.
PMID: 29946150
Free PMC article.
Item in Clipboard
GC skew defines distinct RNA polymerase pause sites in CpG island promoters.
Kellner WA, Bell JS, Vertino PM.
Kellner WA, et al.
Genome Res. 2015 Nov;25(11):1600-9. doi: 10.1101/gr.189068.114. Epub 2015 Aug 14.
Genome Res. 2015.
PMID: 26275623
Free PMC article.
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Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites.
Kellner WA, Van Bortle K, Li L, Ramos E, Takenaka N, Corces VG.
Kellner WA, et al.
Nucleic Acids Res. 2013 Nov;41(20):9274-83. doi: 10.1093/nar/gkt722. Epub 2013 Aug 13.
Nucleic Acids Res. 2013.
PMID: 23945939
Free PMC article.
Item in Clipboard
Genome-wide phosphoacetylation of histone H3 at Drosophila enhancers and promoters.
Kellner WA, Ramos E, Van Bortle K, Takenaka N, Corces VG.
Kellner WA, et al.
Genome Res. 2012 Jun;22(6):1081-8. doi: 10.1101/gr.136929.111. Epub 2012 Apr 16.
Genome Res. 2012.
PMID: 22508764
Free PMC article.
Item in Clipboard
14-3-3 mediates histone cross-talk during transcription elongation in Drosophila.
Karam CS, Kellner WA, Takenaka N, Clemmons AW, Corces VG.
Karam CS, et al. Among authors: kellner wa.
PLoS Genet. 2010 Jun 3;6(6):e1000975. doi: 10.1371/journal.pgen.1000975.
PLoS Genet. 2010.
PMID: 20532201
Free PMC article.
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Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking.
Wang X, Koulov AV, Kellner WA, Riordan JR, Balch WE.
Wang X, et al. Among authors: kellner wa.
Traffic. 2008 Nov;9(11):1878-93. doi: 10.1111/j.1600-0854.2008.00806.x. Epub 2008 Jul 30.
Traffic. 2008.
PMID: 18764821
Free PMC article.
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Uprobe: a genome-wide universal probe resource for comparative physical mapping in vertebrates.
Kellner WA, Sullivan RT, Carlson BH; NISC Comparative Sequencing Program; Thomas JW.
Kellner WA, et al.
Genome Res. 2005 Jan;15(1):166-73. doi: 10.1101/gr.3066805. Epub 2004 Dec 8.
Genome Res. 2005.
PMID: 15590945
Free PMC article.
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