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Elucidation of the in vitro metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time-of-flight mass spectrometry and isotope exchange.
Wind M, Gebhardt K, Grunwald H, Spickermann J, Donzelli M, Kellenberger L, Muller M, Fullhardt P, Schmitt-Hoffmann A, Schleimer M. Wind M, et al. Among authors: kellenberger l. Rapid Commun Mass Spectrom. 2007;21(7):1093-9. doi: 10.1002/rcm.2926. Rapid Commun Mass Spectrom. 2007. PMID: 17318924
Derazantinib: an investigational drug for the treatment of cholangiocarcinoma.
Braun S, McSheehy P, Litherland K, McKernan P, Forster-Gross N, Bachmann F, El-Shemerly M, Dimova-Dobreva M, Polyakova I, Häckl M, Zhou P, Lane H, Kellenberger L, Engelhardt M. Braun S, et al. Among authors: kellenberger l. Expert Opin Investig Drugs. 2021 Nov;30(11):1071-1080. doi: 10.1080/13543784.2021.1995355. Epub 2021 Nov 9. Expert Opin Investig Drugs. 2021. PMID: 34698609 Review.
The fibroblast growth factor receptor inhibitor, derazantinib, has strong efficacy in human gastric tumor models and synergizes with paclitaxel in vivo.
McSheehy PMJ, Forster-Gross N, El Shemerly M, Bachmann F, Roceri M, Hermann N, Spickermann J, Kellenberger L, Lane HA. McSheehy PMJ, et al. Among authors: kellenberger l. Anticancer Drugs. 2023 Apr 1;34(4):532-543. doi: 10.1097/CAD.0000000000001469. Epub 2022 Dec 2. Anticancer Drugs. 2023. PMID: 36729959
Derazantinib, a fibroblast growth factor receptor inhibitor, inhibits colony-stimulating factor receptor-1 in macrophages and tumor cells and in combination with a murine programmed cell death ligand-1-antibody activates the immune environment of murine syngeneic tumor models.
El Shemerly M, Zanini E, Lecoultre M, Walker PR, Kellenberger L, Lane HA, McSheehy PMJ. El Shemerly M, et al. Among authors: kellenberger l. Anticancer Drugs. 2023 Oct 1;34(9):1035-1045. doi: 10.1097/CAD.0000000000001480. Epub 2022 Dec 19. Anticancer Drugs. 2023. PMID: 36729099
21 results