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The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, Presman E, Benard S, Kelleher K, Wilhelm J, Stahl ML, Kriz R, Gao Y, Cao Z, Ling HP, Pangalos MN, Walsh FS, Somers WS. Mosyak L, et al. Among authors: kelleher k. J Biol Chem. 2006 Nov 24;281(47):36378-90. doi: 10.1074/jbc.M607314200. Epub 2006 Sep 27. J Biol Chem. 2006. PMID: 17005555 Free article.
Crystal structure of a human IκB kinase β asymmetric dimer.
Liu S, Misquitta YR, Olland A, Johnson MA, Kelleher KS, Kriz R, Lin LL, Stahl M, Mosyak L. Liu S, et al. J Biol Chem. 2013 Aug 2;288(31):22758-67. doi: 10.1074/jbc.M113.482596. Epub 2013 Jun 21. J Biol Chem. 2013. PMID: 23792959 Free PMC article.
Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation.
Fung E, Kang L, Sapashnik D, Benard S, Sievers A, Liu Y, Yan G, Zhou J, Rodriguez L, Ma W, Stochaj WR, LaVallie E, Wroblewska L, Kelleher K, Tam A, Bezy O, Breen D, Chabot JR, He T, Lin L, Wu Z, Mosyak L. Fung E, et al. Among authors: kelleher k. Sci Rep. 2021 Apr 26;11(1):8921. doi: 10.1038/s41598-021-87959-5. Sci Rep. 2021. PMID: 33903632 Free PMC article.
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
Root AR, Guntas G, Katragadda M, Apgar JR, Narula J, Chang CS, Hanscom S, McKenna M, Wade J, Meade C, Ma W, Guo Y, Liu Y, Duan W, Hendershot C, King AC, Zhang Y, Sousa E, Tam A, Benard S, Yang H, Kelleher K, Jin F, Piche-Nicholas N, Keating SE, Narciandi F, Lawrence-Henderson R, Arai M, Stochaj WR, Svenson K, Mosyak L, Lam K, Francis C, Marquette K, Wroblewska L, Zhu HL, Sheehan AD, LaVallie ER, D'Antona AM, Betts A, King L, Rosfjord E, Cunningham O, Lin L, Sapra P, Tchistiakova L, Mathur D, Bloom L. Root AR, et al. Among authors: kelleher k. MAbs. 2021 Jan-Dec;13(1):1850395. doi: 10.1080/19420862.2020.1850395. MAbs. 2021. PMID: 33459147 Free PMC article.
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design.
Apgar JR, Tam ASP, Sorm R, Moesta S, King AC, Yang H, Kelleher K, Murphy D, D'Antona AM, Yan G, Zhong X, Rodriguez L, Ma W, Ferguson DE, Carven GJ, Bennett EM, Lin L. Apgar JR, et al. Among authors: kelleher k. PLoS One. 2020 May 7;15(5):e0232713. doi: 10.1371/journal.pone.0232713. eCollection 2020. PLoS One. 2020. PMID: 32379792 Free PMC article.
Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation.
Breen DM, Jagarlapudi S, Patel A, Zou C, Joaquim S, Li X, Kang L, Pang J, Hales K, Ziso-Qejvanaj E, Vera NB, Bennett D, He T, Lambert M, Kelleher K, Wu Z, Zhang BB, Lin L, Seeley RJ, Bezy O. Breen DM, et al. Among authors: kelleher k. iScience. 2021 May 19;24(6):102554. doi: 10.1016/j.isci.2021.102554. eCollection 2021 Jun 25. iScience. 2021. PMID: 34189431 Free PMC article.
499 results