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A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl.
Triller G, Vlachou EP, Hashemi H, van Straaten M, Zeelen JP, Kelemen Y, Baehr C, Marker CL, Ruf S, Svirina A, Chandra M, Urban K, Gkeka A, Kruse S, Baumann A, Miller AK, Bartel M, Pravetoni M, Stebbins CE, Papavasiliou FN, Verdi JP. Triller G, et al. Among authors: kelemen y. Cell Rep. 2023 Feb 28;42(2):112049. doi: 10.1016/j.celrep.2023.112049. Epub 2023 Jan 30. Cell Rep. 2023. PMID: 36719797 Free PMC article.
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects.
Urban K, Gkeka A, Chandra M, Greiner D, Pollich S, Ruf S, Kelemen Y, Sundermann T, Pravetoni M, Baehr C, Stebbins CE, Papavasiliou FN, Verdi JP. Urban K, et al. Among authors: kelemen y. Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print. Toxicol Lett. 2024. PMID: 38588756 Free article.