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Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis.
J Org Chem. 2024 Apr 5;89(7):4261-4282. doi: 10.1021/acs.joc.3c01494. Epub 2024 Mar 20.
J Org Chem. 2024.
PMID: 38508870
Free PMC article.
Review.
Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations.
He MM, Zhu SX, Cannon JR, Christensen JK, Duggal R, Gunduz M, Hilgendorf C, Hughes A, Kekessie I, Kullmann M, Leung D, Terjung C, Wang K, Wesche F.
He MM, et al. Among authors: kekessie i.
Drug Metab Dispos. 2023 Nov;51(11):1436-1450. doi: 10.1124/dmd.123.001437. Epub 2023 Aug 17.
Drug Metab Dispos. 2023.
PMID: 37591731
Review.
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Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening.
Hu J, Chan AI, Adaligil E, Kekessie I, Takahashi M, Song A, Cunningham CN, Paegel BM.
Hu J, et al. Among authors: kekessie i.
J Med Chem. 2023 May 11;66(9):6288-6296. doi: 10.1021/acs.jmedchem.3c00138. Epub 2023 Apr 19.
J Med Chem. 2023.
PMID: 37075027
Free PMC article.
Item in Clipboard
Targeted degradation via direct 26S proteasome recruitment.
Bashore C, Prakash S, Johnson MC, Conrad RJ, Kekessie IA, Scales SJ, Ishisoko N, Kleinheinz T, Liu PS, Popovych N, Wecksler AT, Zhou L, Tam C, Zilberleyb I, Srinivasan R, Blake RA, Song A, Staben ST, Zhang Y, Arnott D, Fairbrother WJ, Foster SA, Wertz IE, Ciferri C, Dueber EC.
Bashore C, et al. Among authors: kekessie ia.
Nat Chem Biol. 2023 Jan;19(1):55-63. doi: 10.1038/s41589-022-01218-w. Epub 2022 Dec 28.
Nat Chem Biol. 2023.
PMID: 36577875
Free PMC article.
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A solid-phase approach for the synthesis of muramyl dipeptide conjugates for detection of NOD2.
Kekessie I, Goncharov T, Kőműves LG, Vucic D, Song A.
Kekessie I, et al.
Bioorg Chem. 2021 Nov;116:105360. doi: 10.1016/j.bioorg.2021.105360. Epub 2021 Sep 15.
Bioorg Chem. 2021.
PMID: 34562676
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Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors.
Xiao W, Li T, Bononi FC, Lac D, Kekessie IA, Liu Y, Sanchez E, Mazloom A, Ma AH, Lin J, Tran J, Yang K, Lam KS, Liu R.
Xiao W, et al. Among authors: kekessie ia.
EJNMMI Res. 2016 Dec;6(1):18. doi: 10.1186/s13550-016-0165-z. Epub 2016 Feb 27.
EJNMMI Res. 2016.
PMID: 26922417
Free PMC article.
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