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Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease.
Gulbins A, Horstmann M, Daser A, Flögel U, Oeverhaus M, Bechrakis NE, Banga JP, Keitsch S, Wilker B, Krause G, Hammer GD, Spencer AG, Zeidan R, Eckstein A, Philipp S, Görtz GE. Gulbins A, et al. Among authors: keitsch s. Front Endocrinol (Lausanne). 2023 Jun 26;14:1211473. doi: 10.3389/fendo.2023.1211473. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37435490 Free PMC article.
Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide.
Becker KA, Fahsel B, Kemper H, Mayeres J, Li C, Wilker B, Keitsch S, Soddemann M, Sehl C, Kohnen M, Edwards MJ, Grassmé H, Caldwell CC, Seitz A, Fraunholz M, Gulbins E. Becker KA, et al. Among authors: keitsch s. Infect Immun. 2017 Dec 19;86(1):e00606-17. doi: 10.1128/IAI.00606-17. Print 2018 Jan. Infect Immun. 2017. PMID: 29084896 Free PMC article.
Inhibition of PI-3-K and AKT Amplifies Kv1.3 Inhibitor-Induced Death of Human T Leukemia Cells.
Bergermann T, Born L, Ferguson F, Latkovic P, Scheul A, Sonnenschein N, Leanza L, Keitsch S, Sehl C, Wilker B, Edwards MJ, Zoratti M, Paradisi C, Kohnen M, Szabo I, Becker KA, Carpinteiro A. Bergermann T, et al. Among authors: keitsch s. Cell Physiol Biochem. 2019;53(S1):1-10. doi: 10.33594/000000187. Cell Physiol Biochem. 2019. PMID: 31804046 Free article.
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins E. Edwards MJ, et al. Among authors: keitsch s. J Biol Chem. 2020 Nov 6;295(45):15174-15182. doi: 10.1074/jbc.RA120.015249. Epub 2020 Sep 11. J Biol Chem. 2020. PMID: 32917722 Free PMC article.
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections.
Becker KA, Verhaegh R, Verhasselt HL, Keitsch S, Soddemann M, Wilker B, Wilson GC, Buer J, Ahmad SA, Edwards MJ, Gulbins E. Becker KA, et al. Among authors: keitsch s. Infect Immun. 2021 Jan 19;89(2):e00677-20. doi: 10.1128/IAI.00677-20. Print 2021 Jan 19. Infect Immun. 2021. PMID: 33139382 Free PMC article.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Carpinteiro A, et al. Among authors: keitsch s. Cell Rep Med. 2020 Nov 17;1(8):100142. doi: 10.1016/j.xcrm.2020.100142. Epub 2020 Oct 29. Cell Rep Med. 2020. PMID: 33163980 Free PMC article.
Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice.
Schumacher F, Edwards MJ, Mühle C, Carpinteiro A, Wilson GC, Wilker B, Soddemann M, Keitsch S, Scherbaum N, Müller BW, Lang UE, Linnemann C, Kleuser B, Müller CP, Kornhuber J, Gulbins E. Schumacher F, et al. Among authors: keitsch s. J Biol Chem. 2022 Aug;298(8):102185. doi: 10.1016/j.jbc.2022.102185. Epub 2022 Jun 24. J Biol Chem. 2022. PMID: 35753355 Free PMC article.
Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.
Carstens H, Kalka K, Verhaegh R, Schumacher F, Soddemann M, Wilker B, Keitsch S, Sehl C, Kleuser B, Hübler M, Rauen U, Becker AK, Koch A, Gulbins E, Kamler M. Carstens H, et al. Among authors: keitsch s. PLoS One. 2022 Jul 21;17(7):e0271620. doi: 10.1371/journal.pone.0271620. eCollection 2022. PLoS One. 2022. PMID: 35862397 Free PMC article.
25 results