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The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information.
Morris JH, Soman K, Akbas RE, Zhou X, Smith B, Meng EC, Huang CC, Cerono G, Schenk G, Rizk-Jackson A, Harroud A, Sanders L, Costes SV, Bharat K, Chakraborty A, Pico AR, Mardirossian T, Keiser M, Tang A, Hardi J, Shi Y, Musen M, Israni S, Huang S, Rose PW, Nelson CA, Baranzini SE. Morris JH, et al. Among authors: keiser m. Bioinformatics. 2023 Feb 3;39(2):btad080. doi: 10.1093/bioinformatics/btad080. Bioinformatics. 2023. PMID: 36759942 Free PMC article.
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.
Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D. Bruni G, et al. Among authors: keiser mj. Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30. Nat Chem Biol. 2016. PMID: 27239787 Free PMC article.
The presynaptic component of the serotonergic system is required for clozapine's efficacy.
Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL. Yadav PN, et al. Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3. Neuropsychopharmacology. 2011. PMID: 21048700 Free PMC article.
A biomedical open knowledge network harnesses the power of AI to understand deep human biology.
Baranzini SE, Börner K, Morris J, Nelson CA, Soman K, Schleimer E, Keiser M, Musen M, Pearce R, Reza T, Smith B, Herr BW 2nd, Oskotsky B, Rizk-Jackson A, Rankin KP, Sanders SJ, Bove R, Rose PW, Israni S, Huang S. Baranzini SE, et al. Among authors: keiser m. AI Mag. 2022 Spring;43(1):46-58. doi: 10.1002/aaai.12037. Epub 2022 Mar 31. AI Mag. 2022. PMID: 36093122 Free PMC article.
Learning Molecular Representations for Medicinal Chemistry.
Chuang KV, Gunsalus LM, Keiser MJ. Chuang KV, et al. Among authors: keiser mj. J Med Chem. 2020 Aug 27;63(16):8705-8722. doi: 10.1021/acs.jmedchem.0c00385. Epub 2020 May 15. J Med Chem. 2020. PMID: 32366098 Review.
Quantifying biogenic bias in screening libraries.
Hert J, Irwin JJ, Laggner C, Keiser MJ, Shoichet BK. Hert J, et al. Nat Chem Biol. 2009 Jul;5(7):479-83. doi: 10.1038/nchembio.180. Epub 2009 May 31. Nat Chem Biol. 2009. PMID: 19483698 Free PMC article.
137 results