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Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2H-furo[3,2-b]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells.
Castán A, Badorrey R, Díez JA, Christoffersen CT, Rasmussen LK, Kehler J, Köhler R, Gálvez JA, Díaz-de-Villegas MD. Castán A, et al. Among authors: kehler j. J Org Chem. 2020 May 1;85(9):5941-5951. doi: 10.1021/acs.joc.0c00276. Epub 2020 Apr 16. J Org Chem. 2020. PMID: 32248689
Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain.
Kehler J, Kilburn JP, Estrada S, Christensen SR, Wall A, Thibblin A, Lubberink M, Bundgaard C, Brennum LT, Steiniger-Brach B, Christoffersen CT, Timmermann S, Kreilgaard M, Antoni G, Bang-Andersen B, Nielsen J. Kehler J, et al. J Nucl Med. 2014 Sep;55(9):1513-8. doi: 10.2967/jnumed.114.140178. Epub 2014 Jul 3. J Nucl Med. 2014. PMID: 24994928 Free article.
Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
Hayes J, Laursen B, Eneberg E, Kehler J, Rasmussen LK, Langgard M, Bastlund JF, Gerdjikov TV. Hayes J, et al. Among authors: kehler j. Neuropharmacology. 2021 Mar 15;186:108454. doi: 10.1016/j.neuropharm.2021.108454. Epub 2021 Jan 12. Neuropharmacology. 2021. PMID: 33444639
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.
Khammy MM, Dalsgaard T, Larsen PH, Christoffersen CT, Clausen D, Rasmussen LK, Folkersen L, Grunnet M, Kehler J, Aalkjaer C, Nielsen J. Khammy MM, et al. Among authors: kehler j. Br J Pharmacol. 2017 Nov;174(22):4186-4198. doi: 10.1111/bph.14034. Epub 2017 Oct 15. Br J Pharmacol. 2017. PMID: 28910498 Free PMC article.
97 results