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Is the disease risk and penetrance in Leber hereditary optic neuropathy actually low?
Mackey DA, Ong JS, MacGregor S, Whiteman DC, Craig JE, Lopez Sanchez MIG, Kearns LS, Staffieri SE, Clarke L, McGuinness MB, Meteoukki W, Samuel S, Ruddle JB, Chen C, Fraser CL, Harrison J, Howell N, Hewitt AW. Mackey DA, et al. Among authors: kearns ls. Am J Hum Genet. 2023 Jan 5;110(1):170-176. doi: 10.1016/j.ajhg.2022.11.014. Epub 2022 Dec 23. Am J Hum Genet. 2023. PMID: 36565701 Free PMC article.
What compassionate use means for gene therapies.
Chapman CR, Moch KI, McFadyen A, Kearns L, Watson T, Furlong P, Bateman-House A. Chapman CR, et al. Nat Biotechnol. 2019 Apr;37(4):352-355. doi: 10.1038/s41587-019-0081-7. Nat Biotechnol. 2019. PMID: 30940936 No abstract available.
Rethinking the Belmont Report?
Friesen P, Kearns L, Redman B, Caplan AL. Friesen P, et al. Am J Bioeth. 2017 Jul;17(7):15-21. doi: 10.1080/15265161.2017.1329482. Am J Bioeth. 2017. PMID: 28661753
87 results