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Page 1
Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis.
Bolaños-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, Elmariah H, Rezvani AR, Gooptu M, Larkin KT, Shaffer BC, El Jurdi N, Loren AW, Solh M, Hall AC, Alousi AM, Jamy OH, Perales MA, Yao JM, Applegate K, Bhatt AS, Kean LS, Efebera YA, Reshef R, Clark W, DiFronzo NL, Leifer E, Horowitz MM, Jones RJ, Holtan SG; BMT CTN 1703 Investigators. Bolaños-Meade J, et al. Among authors: kean ls. N Engl J Med. 2023 Jun 22;388(25):2338-2348. doi: 10.1056/NEJMoa2215943. N Engl J Med. 2023. PMID: 37342922 Free PMC article. Clinical Trial.
Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease.
Wobma H, Kapadia M, Kim HT, Alvarez-Calderon F, Baumeister SHC, Duncan C, Forrest S, Gorfinkel L, Huang J, Lehmann LE, Li H, Schwartz M, Koreth J, Ritz J, Kean LS, Whangbo JS. Wobma H, et al. Among authors: kean ls. Blood Adv. 2023 Aug 22;7(16):4647-4657. doi: 10.1182/bloodadvances.2023009729. Blood Adv. 2023. PMID: 37603347 Free PMC article.
Abatacept for graft versus host disease prophylaxis in patients 60 years and older receiving mismatched unrelated donor transplantation for hematologic malignancies.
Raghunandan S, Qayed M, Watkins BK, Graiser M, Gorfinkel L, Westbrook A, Gillespie S, Bratrude B, Petrovic A, Suessmuth Y, Horan J, Kean LS, Langston AA. Raghunandan S, et al. Among authors: kean ls. Bone Marrow Transplant. 2023 Nov;58(11):1264-1266. doi: 10.1038/s41409-023-02043-y. Epub 2023 Aug 14. Bone Marrow Transplant. 2023. PMID: 37580397 Free PMC article. No abstract available.
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice.
Saha A, Palchaudhuri R, Lanieri L, Hyzy S, Riddle MJ, Panthera J, Eide C, Tolar J, Panoskaltsis-Mortari A, Gorfinkel L, Tkachev V, Gerdemann U, Alvarez-Calderon F, Palato ER, MacMillan ML, Wagner JE, Kean LS, Osborn M, Kiem HP, Scadden DT, Olson LM, Blazar BR. Saha A, et al. Among authors: kean ls. Blood. 2024 Mar 6:blood.2023023549. doi: 10.1182/blood.2023023549. Online ahead of print. Blood. 2024. PMID: 38447038
Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation.
Essawi K, Hakami W, Naeem Khan MB, Martin R, Zeng J, Chu R, Uchida N, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Blobel GA, Gerdemann U, Kean LS, Maitland SA, Wolfe SA, Metais JY, Gottschalk S, Bauer DE, Tisdale JF, Demirci S. Essawi K, et al. Among authors: kean ls. Mol Ther Methods Clin Dev. 2023 Apr 20;29:483-493. doi: 10.1016/j.omtm.2023.04.004. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37273902 Free PMC article.
Abatacept for the prevention of GVHD in patients receiving mismatched unrelated transplants: a real-world analysis.
Raghunandan S, Gorfinkel L, Graiser M, Bratrude B, Suessmuth Y, Gillespie S, Westbrook AL, Williams KM, Schoettler ML, Kean LS, Horan J, Langston AA, Qayed M, Watkins B. Raghunandan S, et al. Among authors: kean ls. Blood Adv. 2023 Aug 22;7(16):4395-4399. doi: 10.1182/bloodadvances.2023010225. Blood Adv. 2023. PMID: 37285800 Free PMC article. No abstract available.
The Adverse Event Landscape of Stem Cell Transplant: Evidence for aGVHD Driving Early Transplant Associated Toxicities.
Takahashi T, Watkins B, Bratrude B, Neuberg D, Hebert K, Betz K, Yu A, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Blazar BR, Horan JT, Langston A, Kean LS, Qayed M. Takahashi T, et al. Among authors: kean ls. Transplant Cell Ther. 2024 Apr 6:S2666-6367(24)00317-8. doi: 10.1016/j.jtct.2024.03.030. Online ahead of print. Transplant Cell Ther. 2024. PMID: 38583802
B-cell-directed CAR-T cell therapy activates CD8+ cytotoxic CARneg bystander T-cells in non-human primates and patients.
Kaminski J, Fleming RA, Alvarez-Calderon F, Winschel MB, McGuckin C, Ho EE, Eng F, Rui X, Keskula P, Cagnin L, Charles J, Zavistaski JM, Margossian SP, Kapadia M, Rottman JB, Lane J, Baumeister SHC, Tkachev V, Shalek A, Kean LS, Gerdemann U. Kaminski J, et al. Among authors: kean ls. Blood. 2024 Apr 1:blood.2023022717. doi: 10.1182/blood.2023022717. Online ahead of print. Blood. 2024. PMID: 38558106
Overlap chronic GVHD is associated with adverse survival outcomes compared to classic chronic GVHD.
Gorfinkel L, Raghunandan S, Watkins B, Hebert K, Neuberg DS, Bratrude B, Betz K, Yu A, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Blazar BR, Horan JT, Langston A, Kean LS, Qayed M. Gorfinkel L, et al. Among authors: kean ls. Bone Marrow Transplant. 2024 May;59(5):680-687. doi: 10.1038/s41409-024-02245-y. Epub 2024 Feb 21. Bone Marrow Transplant. 2024. PMID: 38383714
91 results