Kazmi F - Search Results

1

N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, Legenski K, Matico R, Shaffer P, Simonnet Y, Tanner A, Wang CY, Wang W, Attar R, Edwards JP, Kuduk SD. Cisar JS, et al. Among authors: kazmi f. J Med Chem. 2022 Aug 25;65(16):11241-11256. doi: 10.1021/acs.jmedchem.2c00788. Epub 2022 Aug 4. J Med Chem. 2022. PMID: 35925768

2

A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.

DeRatt LG, Christine Pietsch E, Tanner A, Shaffer P, Jacoby E, Wang W, Kazmi F, Zhang X, Attar RM, Edwards JP, Kuduk SD. DeRatt LG, et al. Among authors: kazmi f. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127589. doi: 10.1016/j.bmcl.2020.127589. Epub 2020 Sep 29. Bioorg Med Chem Lett. 2020. PMID: 33007394

3

Characterization of the In Vitro Inhibitory Potential of the Oligonucleotide Imetelstat on Human Cytochrome P450 Enzymes with Predictions of In Vivo Drug-Drug Interactions.

Kazmi F, Sensenhauser C, Greway T. Kazmi F, et al. Drug Metab Dispos. 2019 Jan;47(1):9-14. doi: 10.1124/dmd.118.084103. Epub 2018 Nov 2. Drug Metab Dispos. 2019. PMID: 30389730

4

An Assessment of the In Vitro Inhibition of Cytochrome P450 Enzymes, UDP-Glucuronosyltransferases, and Transporters by Phosphodiester- or Phosphorothioate-Linked Oligonucleotides.

Kazmi F, Yerino P, McCoy C, Parkinson A, Buckley DB, Ogilvie BW. Kazmi F, et al. Drug Metab Dispos. 2018 Aug;46(8):1066-1074. doi: 10.1124/dmd.118.081729. Epub 2018 May 7. Drug Metab Dispos. 2018. PMID: 29735754

5

The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments.

Haupt LJ, Kazmi F, Ogilvie BW, Buckley DB, Smith BD, Leatherman S, Paris B, Parkinson O, Parkinson A. Haupt LJ, et al. Among authors: kazmi f. Drug Metab Dispos. 2015 Nov;43(11):1744-50. doi: 10.1124/dmd.115.066597. Epub 2015 Sep 9. Drug Metab Dispos. 2015. PMID: 26354951

6

An evaluation of the dilution method for identifying metabolism-dependent inhibitors of cytochrome P450 enzymes.

Parkinson A, Kazmi F, Buckley DB, Yerino P, Paris BL, Holsapple J, Toren P, Otradovec SM, Ogilvie BW. Parkinson A, et al. Among authors: kazmi f. Drug Metab Dispos. 2011 Aug;39(8):1370-87. doi: 10.1124/dmd.111.038596. Epub 2011 Apr 27. Drug Metab Dispos. 2011. PMID: 21525169

7

A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.

Kazmi F, Barbara JE, Yerino P, Parkinson A. Kazmi F, et al. Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620. Epub 2015 Jan 16. Drug Metab Dispos. 2015. PMID: 25595597

8

Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor.

Kazmi F, Yerino P, Barbara JE, Parkinson A. Kazmi F, et al. Drug Metab Dispos. 2015 Sep;43(9):1294-302. doi: 10.1124/dmd.115.065011. Epub 2015 Jul 1. Drug Metab Dispos. 2015. PMID: 26135009

9

In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential.

Kazmi F, Haupt LJ, Horkman JR, Smith BD, Buckley DB, Wachter EA, Singer JM. Kazmi F, et al. Xenobiotica. 2014 Jul;44(7):606-14. doi: 10.3109/00498254.2013.878814. Epub 2014 Jan 10. Xenobiotica. 2014. PMID: 24405273

10

System-dependent outcomes during the evaluation of drug candidates as inhibitors of cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) enzymes: human hepatocytes versus liver microsomes versus recombinant enzymes.

Parkinson A, Kazmi F, Buckley DB, Yerino P, Ogilvie BW, Paris BL. Parkinson A, et al. Among authors: kazmi f. Drug Metab Pharmacokinet. 2010;25(1):16-27. doi: 10.2133/dmpk.25.16. Drug Metab Pharmacokinet. 2010. PMID: 20208386 Free article. Review.

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