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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PA, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine KM, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH; PCAWG Structural Variation Working Group; Campbell PJ, Tubio JMC; PCAWG Consortium. Rodriguez-Martin B, et al. Among authors: kazazian hh. Nat Genet. 2020 Mar;52(3):306-319. doi: 10.1038/s41588-019-0562-0. Epub 2020 Feb 5. Nat Genet. 2020. PMID: 32024998 Free PMC article.
LINE-1 expression and retrotransposition in Barrett's esophagus and esophageal carcinoma.
Doucet-O'Hare TT, Rodić N, Sharma R, Darbari I, Abril G, Choi JA, Young Ahn J, Cheng Y, Anders RA, Burns KH, Meltzer SJ, Kazazian HH Jr. Doucet-O'Hare TT, et al. Among authors: kazazian hh jr. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4894-900. doi: 10.1073/pnas.1502474112. Epub 2015 Aug 17. Proc Natl Acad Sci U S A. 2015. PMID: 26283398 Free PMC article.
A mouse model of human L1 retrotransposition.
Ostertag EM, DeBerardinis RJ, Goodier JL, Zhang Y, Yang N, Gerton GL, Kazazian HH Jr. Ostertag EM, et al. Among authors: kazazian hh jr. Nat Genet. 2002 Dec;32(4):655-60. doi: 10.1038/ng1022. Epub 2002 Nov 4. Nat Genet. 2002. PMID: 12415270
Active human retrotransposons: variation and disease.
Hancks DC, Kazazian HH Jr. Hancks DC, et al. Among authors: kazazian hh jr. Curr Opin Genet Dev. 2012 Jun;22(3):191-203. doi: 10.1016/j.gde.2012.02.006. Epub 2012 Mar 8. Curr Opin Genet Dev. 2012. PMID: 22406018 Free PMC article. Review.
Allelic heterogeneity in LINE-1 retrotransposition activity.
Lutz SM, Vincent BJ, Kazazian HH Jr, Batzer MA, Moran JV. Lutz SM, et al. Among authors: kazazian hh jr. Am J Hum Genet. 2003 Dec;73(6):1431-7. doi: 10.1086/379744. Epub 2003 Nov 7. Am J Hum Genet. 2003. PMID: 14610717 Free PMC article.
Extensive somatic L1 retrotransposition in colorectal tumors.
Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, Burns MB, Harris RS, Sigmon DF, Casella A, Erlanger B, Wheelan S, Upton KR, Shukla R, Faulkner GJ, Largaespada DA, Kazazian HH Jr. Solyom S, et al. Among authors: kazazian hh jr. Genome Res. 2012 Dec;22(12):2328-38. doi: 10.1101/gr.145235.112. Epub 2012 Sep 11. Genome Res. 2012. PMID: 22968929 Free PMC article.
Striking heterogeneity of somatic L1 retrotransposition in single normal and cancerous gastrointestinal cells.
Yamaguchi K, Soares AO, Goff LA, Talasila A, Choi JA, Ivenitsky D, Karma S, Brophy B, Devine SE, Meltzer SJ, Kazazian HH Jr. Yamaguchi K, et al. Among authors: kazazian hh jr. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32215-32222. doi: 10.1073/pnas.2019450117. Epub 2020 Dec 4. Proc Natl Acad Sci U S A. 2020. PMID: 33277430 Free PMC article.
349 results