Kawamura S - Search Results

1

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.

Vara BA, Levi SM, Achab A, Candito DA, Fradera X, Lesburg CA, Kawamura S, Lacey BM, Lim J, Methot JL, Xu Z, Xu H, Smith DM, Piesvaux JA, Miller JR, Bittinger M, Ranganath SH, Bennett DJ, DiMauro EF, Pasternak A. Vara BA, et al. Among authors: kawamura s. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661. doi: 10.1021/acsmedchemlett.1c00096. eCollection 2021 Apr 8. ACS Med Chem Lett. 2021. PMID: 33859804 Free PMC article.

2

Identification of Potent Reverse Indazole Inhibitors for HPK1.

Yu EC, Methot JL, Fradera X, Lesburg CA, Lacey BM, Siliphaivanh P, Liu P, Smith DM, Xu Z, Piesvaux JA, Kawamura S, Xu H, Miller JR, Bittinger M, Pasternak A. Yu EC, et al. Among authors: kawamura s. ACS Med Chem Lett. 2021 Mar 1;12(3):459-466. doi: 10.1021/acsmedchemlett.0c00672. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738073 Free PMC article.

3

Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).

Palte RL, Schneider SE, Altman MD, Hayes RP, Kawamura S, Lacey BM, Mansueto MS, Reutershan M, Siliphaivanh P, Sondey C, Xu H, Xu Z, Ye Y, Machacek MR. Palte RL, et al. Among authors: kawamura s. ACS Med Chem Lett. 2020 Aug 7;11(9):1688-1693. doi: 10.1021/acsmedchemlett.9b00525. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32944135 Free PMC article.

4

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.

Quiroz RV, Reutershan MH, Schneider SE, Sloman D, Lacey BM, Swalm BM, Yeung CS, Gibeau C, Spellman DS, Rankic DA, Chen D, Witter D, Linn D, Munsell E, Feng G, Xu H, Hughes JME, Lim J, Saurí J, Geddes K, Wan M, Mansueto MS, Follmer NE, Fier PS, Siliphaivanh P, Daublain P, Palte RL, Hayes RP, Lee S, Kawamura S, Silverman S, Sanyal S, Henderson TJ, Ye Y, Gao Y, Nicholson B, Machacek MR. Quiroz RV, et al. Among authors: kawamura s. J Med Chem. 2021 Apr 8;64(7):3911-3939. doi: 10.1021/acs.jmedchem.0c02083. Epub 2021 Mar 23. J Med Chem. 2021. PMID: 33755451

5

Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.

Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S. Kawamura S, et al. J Med Chem. 2014 Mar 27;57(6):2726-35. doi: 10.1021/jm500045x. Epub 2014 Feb 25. J Med Chem. 2014. PMID: 24524217

6

Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.

Kawamura S, Palte RL, Kim HY, Saurí J, Sondey C, Mansueto MS, Altman MD, Machacek MR. Kawamura S, et al. Bioorg Med Chem. 2022 Jul 15;66:116820. doi: 10.1016/j.bmc.2022.116820. Epub 2022 May 14. Bioorg Med Chem. 2022. PMID: 35594650

7

Investigation of the noncovalent binding mode of covalent proteasome inhibitors around the transition state by combined use of cyclopropylic strain-based conformational restriction and computational modeling.

Kawamura S, Unno Y, Tanaka M, Sasaki T, Yamano A, Hirokawa T, Kameda T, Asai A, Arisawa M, Shuto S. Kawamura S, et al. J Med Chem. 2013 Jul 25;56(14):5829-42. doi: 10.1021/jm400542h. Epub 2013 Jul 9. J Med Chem. 2013. PMID: 23837692

8

Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand.

Kawamura S, Ito Y, Hirokawa T, Hikiyama E, Yamada S, Shuto S. Kawamura S, et al. J Med Chem. 2018 May 10;61(9):4020-4029. doi: 10.1021/acs.jmedchem.8b00041. Epub 2018 Apr 20. J Med Chem. 2018. PMID: 29652494

9

Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.

Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S. Kawamura S, et al. Bioorg Med Chem. 2014 Jun 15;22(12):3091-5. doi: 10.1016/j.bmc.2014.04.032. Epub 2014 Apr 24. Bioorg Med Chem. 2014. PMID: 24814885

10

Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.

Kawamura S, Unno Y, List A, Mizuno A, Tanaka M, Sasaki T, Arisawa M, Asai A, Groll M, Shuto S. Kawamura S, et al. J Med Chem. 2013 May 9;56(9):3689-700. doi: 10.1021/jm4002296. Epub 2013 Apr 22. J Med Chem. 2013. PMID: 23547757

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