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Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist.
Sakagami K, Yasuhara A, Chaki S, Yoshikawa R, Kawakita Y, Saito A, Taguchi T, Nakazato A. Sakagami K, et al. Among authors: kawakita y. Bioorg Med Chem. 2008 Apr 15;16(8):4359-66. doi: 10.1016/j.bmc.2008.02.066. Epub 2008 Feb 26. Bioorg Med Chem. 2008. PMID: 18348906
In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid), a potent metabotropic glutamate receptor antagonist.
Nakamura M, Kawakita Y, Yasuhara A, Fukasawa Y, Yoshida K, Sakagami K, Nakazato A. Nakamura M, et al. Among authors: kawakita y. Drug Metab Dispos. 2006 Mar;34(3):369-74. doi: 10.1124/dmd.105.006213. Epub 2005 Dec 2. Drug Metab Dispos. 2006. PMID: 16326817
Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia.
Chaki S, Shimazaki T, Karasawa J, Aoki T, Kaku A, Iijima M, Kambe D, Yamamoto S, Kawakita Y, Shibata T, Abe K, Okubo T, Sekiguchi Y, Okuyama S. Chaki S, et al. Among authors: kawakita y. Psychopharmacology (Berl). 2015 Aug;232(15):2849-61. doi: 10.1007/s00213-015-3920-3. Epub 2015 Apr 15. Psychopharmacology (Berl). 2015. PMID: 25869273
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, Yamamoto K. Kakinuma H, et al. Among authors: kawakita y. J Med Chem. 2010 Apr 22;53(8):3247-61. doi: 10.1021/jm901893x. J Med Chem. 2010. PMID: 20302302
Novel Compound Induces Erythropoietin Secretion through Liver Effects in Chronic Kidney Disease Patients and Healthy Volunteers.
Shinfuku A, Shimazaki T, Fujiwara M, Sato F, Watase H, Numazaki T, Kawakita Y, Mutoh M, Yamasaki H, Takayama N, Kato S, Sugimoto T, Maruyama J. Shinfuku A, et al. Among authors: kawakita y. Am J Nephrol. 2018;48(3):157-164. doi: 10.1159/000492181. Epub 2018 Sep 3. Am J Nephrol. 2018. PMID: 30176654 Free PMC article. Clinical Trial.
166 results