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Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.
Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N, Sameshima H, Hosokawa K, Harada Y, Shrestha B, Yamamoto M, Morimoto-Yamashita Y, Kikuchi H, Kiyama R, Kamikokuryo C, Tancharoen S, Sakakima H, Morioka M, Tanaka E, Ito T, Maruyama I. Kikuchi K, et al. Among authors: kawahara ki. Oxid Med Cell Longev. 2017;2017:6873281. doi: 10.1155/2017/6873281. Epub 2017 Nov 10. Oxid Med Cell Longev. 2017. PMID: 29259732 Free PMC article.
Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.
Kikuchi K, Setoyama K, Tanaka E, Otsuka S, Terashi T, Nakanishi K, Takada S, Sakakima H, Ampawong S, Kawahara KI, Nagasato T, Hosokawa K, Harada Y, Yamamoto M, Kamikokuryo C, Kiyama R, Morioka M, Ito T, Maruyama I, Tancharoen S. Kikuchi K, et al. Among authors: kawahara ki. Sci Rep. 2018 Oct 26;8(1):15844. doi: 10.1038/s41598-018-34220-1. Sci Rep. 2018. PMID: 30367108 Free PMC article.
Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model.
Kikuchi K, Setoyama K, Terashi T, Sumizono M, Tancharoen S, Otsuka S, Takada S, Nakanishi K, Ueda K, Sakakima H, Kawahara KI, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H. Kikuchi K, et al. Among authors: kawahara ki. Int J Mol Sci. 2018 May 18;19(5):1513. doi: 10.3390/ijms19051513. Int J Mol Sci. 2018. PMID: 29783695 Free PMC article.
E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model.
Kikuchi K, Setoyama K, Takada S, Otsuka S, Nakanishi K, Norimatsu K, Tani A, Sakakima H, Kawahara KI, Hosokawa K, Kiyama R, Sumizono M, Tancharoen S, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H. Kikuchi K, et al. Among authors: kawahara ki. Int J Mol Sci. 2020 Jun 1;21(11):3972. doi: 10.3390/ijms21113972. Int J Mol Sci. 2020. PMID: 32492845 Free PMC article.
The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.
Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I. Kikuchi K, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):865-74. doi: 10.1124/jpet.108.149484. Epub 2009 Mar 17. J Pharmacol Exp Ther. 2009. PMID: 19293391
Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.
Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I, Kawahara K. Kikuchi K, et al. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1121-5. doi: 10.1016/j.bbrc.2009.09.015. Epub 2009 Sep 6. Biochem Biophys Res Commun. 2009. PMID: 19737535
Edaravone: a new therapeutic approach for the treatment of acute stroke.
Kikuchi K, Kawahara K, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Tancharoen S, Miura N, Takenouchi K, Oyama Y, Shrestha B, Matsuda F, Yoshida Y, Arimura S, Mera K, Tada K, Yoshinaga N, Maenosono R, Ohno Y, Hashiguchi T, Maruyama I, Shigemori M. Kikuchi K, et al. Med Hypotheses. 2010 Dec;75(6):583-5. doi: 10.1016/j.mehy.2010.07.038. Epub 2010 Aug 21. Med Hypotheses. 2010. PMID: 20728280
Beyond neurological disease: new targets for edaravone (Review).
Kikuchi K, Uchikado H, Miyagi N, Morimoto Y, Ito T, Tancharoen S, Miura N, Miyata K, Sakamoto R, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Kawahara K. Kikuchi K, et al. Int J Mol Med. 2011 Dec;28(6):899-906. doi: 10.3892/ijmm.2011.795. Epub 2011 Sep 15. Int J Mol Med. 2011. PMID: 21922128 Review.
Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I. Nakahara M, et al. PLoS One. 2013 Sep 30;8(9):e75961. doi: 10.1371/journal.pone.0075961. eCollection 2013. PLoS One. 2013. PMID: 24098750 Free PMC article.
100 results