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Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.
Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T. Tanaka S, et al. Among authors: kawabata t. Hepatology. 2016 Dec;64(6):1994-2014. doi: 10.1002/hep.28820. Epub 2016 Oct 21. Hepatology. 2016. PMID: 27637015
Suppression of autophagic activity by Rubicon is a signature of aging.
Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T. Nakamura S, et al. Among authors: kawabata t. Nat Commun. 2019 Feb 19;10(1):847. doi: 10.1038/s41467-019-08729-6. Nat Commun. 2019. PMID: 30783089 Free PMC article.
Autophagosome biogenesis and human health.
Kawabata T, Yoshimori T. Kawabata T, et al. Cell Discov. 2020 Jun 2;6(1):33. doi: 10.1038/s41421-020-0166-y. eCollection 2020. Cell Discov. 2020. PMID: 32528724 Free PMC article. Review.
Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.
Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, Fujiwara M, Enokidani Y, Yoshida G, Tabata K, Hamasaki M, Kuma A, Yamamoto K, Shimomura I, Yoshimori T. Yamamuro T, et al. Among authors: kawabata t. Nat Commun. 2020 Aug 18;11(1):4150. doi: 10.1038/s41467-020-17985-w. Nat Commun. 2020. PMID: 32811819 Free PMC article.
881 results