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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
MAbs. 2018 Feb/Mar;10(2):244-255. doi: 10.1080/19420862.2017.1417718. Epub 2018 Jan 29.
MAbs. 2018.
PMID: 29271699
Free PMC article.
Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.
Avery LB, Wang M, Kavosi MS, Joyce A, Kurz JC, Fan YY, Dowty ME, Zhang M, Zhang Y, Cheng A, Hua F, Jones HM, Neubert H, Polzer RJ, O'Hara DM.
Avery LB, et al. Among authors: kavosi ms.
MAbs. 2016 Aug-Sep;8(6):1064-78. doi: 10.1080/19420862.2016.1193660. Epub 2016 May 27.
MAbs. 2016.
PMID: 27232760
Free PMC article.
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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.
Piche-Nicholas NM, Avery LB, King AC, Kavosi M, Wang M, O'Hara DM, Tchistiakova L, Katragadda M.
Piche-Nicholas NM, et al.
MAbs. 2018 Jan;10(1):81-94. doi: 10.1080/19420862.2017.1389355. Epub 2017 Nov 3.
MAbs. 2018.
PMID: 28991504
Free PMC article.
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Comparison of succinimidyl [(125)I]iodobenzoate with iodogen iodination methods to study pharmacokinetics and ADME of biotherapeutics.
Chen J, Wang M, Joyce A, DeFranco D, Kavosi M, Xu X, O'Hara DM.
Chen J, et al.
Pharm Res. 2014 Oct;31(10):2810-21. doi: 10.1007/s11095-014-1378-3. Epub 2014 May 21.
Pharm Res. 2014.
PMID: 24844406
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Bioanalytical platform comparison using a generic human IgG PK assay format.
Leary BA, Lawrence-Henderson R, Mallozzi C, Fernandez Ocaña M, Duriga N, O'Hara DM, Kavosi M, Qu Q, Joyce AP.
Leary BA, et al.
J Immunol Methods. 2013 Nov 29;397(1-2):28-36. doi: 10.1016/j.jim.2013.08.009. Epub 2013 Aug 29.
J Immunol Methods. 2013.
PMID: 23994108
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Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing.
Weng Y, Ishino T, Sievers A, Talukdar S, Chabot JR, Tam A, Duan W, Kerns K, Sousa E, He T, Logan A, Lee D, Li D, Zhou Y, Bernardo B, Joyce A, Kavosi M, O'Hara DM, Clark T, Guo J, Giragossian C, Stahl M, Calle RA, Kriz R, Somers W, Lin L.
Weng Y, et al.
Sci Rep. 2018 Mar 9;8(1):4241. doi: 10.1038/s41598-018-22456-w.
Sci Rep. 2018.
PMID: 29523796
Free PMC article.
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