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Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.
Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjärn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S. Elmén J, et al. Among authors: kauppinen s. Nucleic Acids Res. 2008 Mar;36(4):1153-62. doi: 10.1093/nar/gkm1113. Epub 2007 Dec 23. Nucleic Acids Res. 2008. PMID: 18158304 Free PMC article.
LNA-mediated microRNA silencing in non-human primates.
Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S. Elmén J, et al. Among authors: kauppinen s. Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26. Nature. 2008. PMID: 18368051
Targeting of microRNAs for therapeutics.
Stenvang J, Lindow M, Kauppinen S. Stenvang J, et al. Among authors: kauppinen s. Biochem Soc Trans. 2008 Dec;36(Pt 6):1197-200. doi: 10.1042/BST0361197. Biochem Soc Trans. 2008. PMID: 19021524
Silencing of microRNA families by seed-targeting tiny LNAs.
Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S. Obad S, et al. Among authors: kauppinen s. Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786. Nat Genet. 2011. PMID: 21423181 Free PMC article.
Discovering the first microRNA-targeted drug.
Lindow M, Kauppinen S. Lindow M, et al. Among authors: kauppinen s. J Cell Biol. 2012 Oct 29;199(3):407-12. doi: 10.1083/jcb.201208082. J Cell Biol. 2012. PMID: 23109665 Free PMC article.
Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.
Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Rottiers V, et al. Among authors: kauppinen s. Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840. Sci Transl Med. 2013. PMID: 24259050 Free PMC article.
170 results