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Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor.
Bioorg Med Chem Lett. 2016 Dec 15;26(24):5977-5984. doi: 10.1016/j.bmcl.2016.10.079. Epub 2016 Nov 1.
Bioorg Med Chem Lett. 2016.
PMID: 27865703
Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors.
Banerjee A, Pawar MY, Patil S, Yadav PS, Kadam PA, Kattige VG, Deshpande DS, Pednekar PV, Pisat MK, Gharat LA.
Banerjee A, et al. Among authors: kattige vg.
Bioorg Med Chem Lett. 2014 Oct 15;24(20):4838-44. doi: 10.1016/j.bmcl.2014.08.056. Epub 2014 Sep 2.
Bioorg Med Chem Lett. 2014.
PMID: 25260492
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Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.
Muthukaman N, Tambe M, Shaikh M, Pisal D, Deshmukh S, Tondlekar S, Sarode N, Narayana L, Gajera JM, Kattige VG, Honnegowda S, Karande V, Kulkarni A, Behera D, Jadhav SB, Gudi GS, Khairatkar-Joshi N, Gharat LA.
Muthukaman N, et al. Among authors: kattige vg.
Bioorg Med Chem Lett. 2017 Jun 1;27(11):2594-2601. doi: 10.1016/j.bmcl.2017.03.068. Epub 2017 Mar 24.
Bioorg Med Chem Lett. 2017.
PMID: 28400234
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Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.
Muthukaman N, Tambe M, Deshmukh S, Pisal D, Tondlekar S, Shaikh M, Sarode N, Kattige VG, Pisat M, Sawant P, Honnegowda S, Karande V, Kulkarni A, Behera D, Jadhav SB, Sangana RR, Gudi GS, Khairatkar-Joshi N, Gharat LA.
Muthukaman N, et al. Among authors: kattige vg.
Bioorg Med Chem Lett. 2017 Dec 1;27(23):5131-5138. doi: 10.1016/j.bmcl.2017.10.062.
Bioorg Med Chem Lett. 2017.
PMID: 29100801
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Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.
Muthukaman N, Deshmukh S, Tambe M, Pisal D, Tondlekar S, Shaikh M, Sarode N, Kattige VG, Sawant P, Pisat M, Karande V, Honnegowda S, Kulkarni A, Behera D, Jadhav SB, Sangana RR, Gudi GS, Khairatkar-Joshi N, Gharat LA.
Muthukaman N, et al. Among authors: kattige vg.
Bioorg Med Chem Lett. 2018 Apr 15;28(7):1211-1218. doi: 10.1016/j.bmcl.2018.02.048. Epub 2018 Feb 28.
Bioorg Med Chem Lett. 2018.
PMID: 29519738
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Characterization of domains of the phosphoriboprotein P0 of Plasmodium falciparum.
Chatterjee S, Singh S, Sohoni R, Kattige V, Deshpande C, Chiplunkar S, Kumar N, Sharma S.
Chatterjee S, et al.
Mol Biochem Parasitol. 2000 Apr 15;107(2):143-54. doi: 10.1016/s0166-6851(99)00226-1.
Mol Biochem Parasitol. 2000.
PMID: 10779592
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