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Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate.
Aoyama H, Ijuin R, Kato JY, Urushiyama S, Tetsuhashi M, Hashimoto Y, Yokomatsu T. Aoyama H, et al. Among authors: kato jy. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3676-80. doi: 10.1016/j.bmcl.2015.06.039. Epub 2015 Jun 17. Bioorg Med Chem Lett. 2015. PMID: 26122211
Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept.
Hasumi K, Sato S, Saito T, Kato JY, Shirota K, Sato J, Suzuki H, Ohta S. Hasumi K, et al. Among authors: kato jy. Bioorg Med Chem. 2014 Aug 1;22(15):4162-76. doi: 10.1016/j.bmc.2014.05.045. Epub 2014 Jun 3. Bioorg Med Chem. 2014. PMID: 24938496
71 results