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8,993 results

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Page 1
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19.
Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C; Bonn COVIMMUNE Consortium; Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C. Karagiannis F, et al. Among authors: kato h. Nature. 2022 Sep;609(7928):801-807. doi: 10.1038/s41586-022-05128-8. Epub 2022 Jul 28. Nature. 2022. PMID: 35901960 Free PMC article.
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Häcker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tüting T, Hartmann G. Poeck H, et al. Among authors: kato h. Nat Med. 2008 Nov;14(11):1256-63. doi: 10.1038/nm.1887. Epub 2008 Nov 2. Nat Med. 2008. PMID: 18978796
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. Schlee M, et al. Among authors: kato h. Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2. Immunity. 2009. PMID: 19576794 Free PMC article.
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases.
Bergant V, Yamada S, Grass V, Tsukamoto Y, Lavacca T, Krey K, Mühlhofer MT, Wittmann S, Ensser A, Herrmann A, Vom Hemdt A, Tomita Y, Matsuyama S, Hirokawa T, Huang Y, Piras A, Jakwerth CA, Oelsner M, Thieme S, Graf A, Krebs S, Blum H, Kümmerer BM, Stukalov A, Schmidt-Weber CB, Igarashi M, Gramberg T, Pichlmair A, Kato H. Bergant V, et al. Among authors: kato h. EMBO J. 2022 Sep 1;41(17):e111608. doi: 10.15252/embj.2022111608. Epub 2022 Jul 25. EMBO J. 2022. PMID: 35833542 Free PMC article.
5'-Triphosphate RNA is the ligand for RIG-I.
Hornung V, Ellegast J, Kim S, Brzózka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G. Hornung V, et al. Among authors: kato h. Science. 2006 Nov 10;314(5801):994-7. doi: 10.1126/science.1132505. Epub 2006 Oct 12. Science. 2006. PMID: 17038590
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J. Poeck H, et al. Among authors: kato h. Nat Immunol. 2010 Jan;11(1):63-9. doi: 10.1038/ni.1824. Epub 2009 Nov 15. Nat Immunol. 2010. PMID: 19915568
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Koenig PA, et al. Among authors: kato h. Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12. Science. 2021. PMID: 33436526 Free PMC article.
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Tsukamoto Y, et al. Among authors: kato h. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. Science. 2023. PMID: 36758070
8,993 results