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Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia.
Bartlett MJ, Flores AJ, Ye T, Smidt SI, Dollish HK, Stancati JA, Farrell DC, Parent KL, Doyle KP, Besselsen DG, Heien ML, Cowen SL, Steece-Collier K, Sherman SJ, Falk T. Bartlett MJ, et al. Among authors: parent kl. Exp Neurol. 2020 Nov;333:113413. doi: 10.1016/j.expneurol.2020.113413. Epub 2020 Jul 25. Exp Neurol. 2020. PMID: 32717354 Free PMC article.
The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia.
Flores AJ, Bartlett MJ, Root BK, Parent KL, Heien ML, Porreca F, Polt R, Sherman SJ, Falk T. Flores AJ, et al. Among authors: parent kl. Neuropharmacology. 2018 Oct;141:260-271. doi: 10.1016/j.neuropharm.2018.09.005. Epub 2018 Sep 7. Neuropharmacology. 2018. PMID: 30201210 Free PMC article.
Platform to Enable Combined Measurement of Dopamine and Neural Activity.
Parent KL, Hill DF, Crown LM, Wiegand JP, Gies KF, Miller MA, Atcherley CW, Heien ML, Cowen SL. Parent KL, et al. Anal Chem. 2017 Mar 7;89(5):2790-2799. doi: 10.1021/acs.analchem.6b03642. Epub 2017 Feb 17. Anal Chem. 2017. PMID: 28211999 Free PMC article.
The coaction of tonic and phasic dopamine dynamics.
Atcherley CW, Wood KM, Parent KL, Hashemi P, Heien ML. Atcherley CW, et al. Among authors: parent kl. Chem Commun (Camb). 2015 Feb 11;51(12):2235-8. doi: 10.1039/c4cc06165a. Chem Commun (Camb). 2015. PMID: 25249291 Free PMC article.
12 results