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The role of stem cell niche in intestinal aging.
Pentinmikko N, Katajisto P. Pentinmikko N, et al. Among authors: katajisto p. Mech Ageing Dev. 2020 Oct;191:111330. doi: 10.1016/j.mad.2020.111330. Epub 2020 Aug 14. Mech Ageing Dev. 2020. PMID: 32805262 Free article. Review.
Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development.
George JJ, Oittinen M, Martin-Diaz L, Zapilko V, Iqbal S, Rintakangas T, Arrojo Martins FT, Niskanen H, Katajisto P, Kaikkonen MU, Viiri K. George JJ, et al. Among authors: katajisto p. Cell Mol Gastroenterol Hepatol. 2021;12(3):873-889. doi: 10.1016/j.jcmgh.2021.05.014. Epub 2021 May 28. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34058415 Free PMC article.
WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas.
Aavikko M, Kaasinen E, Andersson N, Pentinmikko N, Sulo P, Donner I, Pihlajamaa P, Kuosmanen A, Bramante S, Katainen R, Sipilä LJ, Martin S, Arola J, Carpén O, Heiskanen I, Mecklin JP, Taipale J, Ristimäki A, Lehti K, Gucciardo E, Katajisto P, Schalin-Jäntti C, Vahteristo P, Aaltonen LA. Aavikko M, et al. Among authors: katajisto p. Hum Mol Genet. 2021 Nov 30;30(24):2429-2440. doi: 10.1093/hmg/ddab206. Hum Mol Genet. 2021. PMID: 34274970 Free PMC article.
Cellular shape reinforces niche to stem cell signaling in the small intestine.
Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P. Pentinmikko N, et al. Among authors: katajisto p. Sci Adv. 2022 Oct 14;8(41):eabm1847. doi: 10.1126/sciadv.abm1847. Epub 2022 Oct 14. Sci Adv. 2022. PMID: 36240269 Free PMC article.
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera FJ, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH. Roper J, et al. Among authors: katajisto p. Nat Biotechnol. 2017 Jun;35(6):569-576. doi: 10.1038/nbt.3836. Epub 2017 May 1. Nat Biotechnol. 2017. PMID: 28459449 Free PMC article.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ. Flanagan DJ, et al. Among authors: katajisto p. Nature. 2021 Jun;594(7863):430-435. doi: 10.1038/s41586-021-03525-z. Epub 2021 Jun 2. Nature. 2021. PMID: 34079124 Free PMC article.
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P. Pentinmikko N, et al. Among authors: katajisto p. Nature. 2019 Jul;571(7765):398-402. doi: 10.1038/s41586-019-1383-0. Epub 2019 Jul 10. Nature. 2019. PMID: 31292548 Free PMC article.
Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.
Udd L, Katajisto P, Rossi DJ, Lepistö A, Lahesmaa AM, Ylikorkala A, Järvinen HJ, Ristimäki AP, Mäkelä TP. Udd L, et al. Among authors: katajisto p. Gastroenterology. 2004 Oct;127(4):1030-7. doi: 10.1053/j.gastro.2004.07.059. Gastroenterology. 2004. PMID: 15480979
42 results