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Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.
Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM. Silva LM, et al. Among authors: kastrup cj. Science. 2021 Dec 24;374(6575):eabl5450. doi: 10.1126/science.abl5450. Epub 2021 Dec 24. Science. 2021. PMID: 34941394
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA.
Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ. Juang LJ, et al. Among authors: kastrup cj. Blood. 2022 Mar 3;139(9):1302-1311. doi: 10.1182/blood.2021014559. Blood. 2022. PMID: 34958662 Free PMC article.
Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state.
Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Leung J, Zhao P, López DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML. Hernandez GE, et al. Among authors: kastrup cj. Nat Cardiovasc Res. 2022 Jan;1(1):67-84. doi: 10.1038/s44161-021-00006-4. Epub 2022 Jan 12. Nat Cardiovasc Res. 2022. PMID: 35599984 Free PMC article.
Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies.
Hur WS, King KC, Patel YN, Nguyen YV, Wei Z, Yang Y, Juang LJ, Leung J, Kastrup CJ, Wolberg AS, Luyendyk JP, Flick MJ. Hur WS, et al. Among authors: kastrup cj. J Thromb Haemost. 2022 Dec;20(12):2873-2886. doi: 10.1111/jth.15877. Epub 2022 Oct 11. J Thromb Haemost. 2022. PMID: 36111375 Free PMC article.
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, MacDougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG. Kastrup CJ, et al. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21444-9. doi: 10.1073/pnas.1217972110. Epub 2012 Dec 11. Proc Natl Acad Sci U S A. 2012. PMID: 23236189 Free PMC article.
59 results