Kastner DL - Search Results

1

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. Coll RC, et al. Among authors: kastner dl. Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16. Nat Med. 2015. PMID: 25686105 Free PMC article.

2

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, Hofmann SR, Stein L, Russo R, Goldsmith D, Dent P, Rosenberg HF, Austin F, Remmers EF, Balow JE Jr, Rosenzweig S, Komarow H, Shoham NG, Wood G, Jones J, Mangra N, Carrero H, Adams BS, Moore TL, Schikler K, Hoffman H, Lovell DJ, Lipnick R, Barron K, O'Shea JJ, Kastner DL, Goldbach-Mansky R. Aksentijevich I, et al. Among authors: kastner dl. Arthritis Rheum. 2002 Dec;46(12):3340-8. doi: 10.1002/art.10688. Arthritis Rheum. 2002. PMID: 12483741 Free PMC article.

3

The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations.

Hull KM, Shoham N, Chae JJ, Aksentijevich I, Kastner DL. Hull KM, et al. Among authors: kastner dl. Curr Opin Rheumatol. 2003 Jan;15(1):61-9. doi: 10.1097/00002281-200301000-00011. Curr Opin Rheumatol. 2003. PMID: 12496512 Review.

4

Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis.

Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, Liu PP, Kastner DL. Chae JJ, et al. Among authors: kastner dl. Mol Cell. 2003 Mar;11(3):591-604. doi: 10.1016/s1097-2765(03)00056-x. Mol Cell. 2003. PMID: 12667444 Free article.

5

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL. Chae JJ, et al. Among authors: kastner dl. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9982-7. doi: 10.1073/pnas.0602081103. Epub 2006 Jun 19. Proc Natl Acad Sci U S A. 2006. PMID: 16785446 Free PMC article.

6

Recent advances in the molecular pathogenesis of hereditary recurrent fevers.

Masters SL, Lobito AA, Chae J, Kastner DL. Masters SL, et al. Among authors: kastner dl. Curr Opin Allergy Clin Immunol. 2006 Dec;6(6):428-33. doi: 10.1097/ACI.0b013e3280109b57. Curr Opin Allergy Clin Immunol. 2006. PMID: 17088647 Review.

7

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.

Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, Gumucio DL, Shoham NG, Kastner DL. Chae JJ, et al. Among authors: kastner dl. Blood. 2008 Sep 1;112(5):1794-803. doi: 10.1182/blood-2008-01-134932. Epub 2008 Jun 24. Blood. 2008. PMID: 18577712 Free PMC article.

8

Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*).

Masters SL, Simon A, Aksentijevich I, Kastner DL. Masters SL, et al. Among authors: kastner dl. Annu Rev Immunol. 2009;27:621-68. doi: 10.1146/annurev.immunol.25.022106.141627. Annu Rev Immunol. 2009. PMID: 19302049 Free PMC article. Review.

9

Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy.

Chae JJ, Aksentijevich I, Kastner DL. Chae JJ, et al. Among authors: kastner dl. Br J Haematol. 2009 Sep;146(5):467-78. doi: 10.1111/j.1365-2141.2009.07733.x. Epub 2009 May 14. Br J Haematol. 2009. PMID: 19466978 Free PMC article. Review.

10

Familial Mediterranean fever with a single MEFV mutation: where is the second hit?

Booty MG, Chae JJ, Masters SL, Remmers EF, Barham B, Le JM, Barron KS, Holland SM, Kastner DL, Aksentijevich I. Booty MG, et al. Among authors: kastner dl. Arthritis Rheum. 2009 Jun;60(6):1851-61. doi: 10.1002/art.24569. Arthritis Rheum. 2009. PMID: 19479870 Free PMC article.

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