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CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours.
Kruse B, Buzzai AC, Shridhar N, Braun AD, Gellert S, Knauth K, Pozniak J, Peters J, Dittmann P, Mengoni M, van der Sluis TC, Höhn S, Antoranz A, Krone A, Fu Y, Yu D, Essand M, Geffers R, Mougiakakos D, Kahlfuß S, Kashkar H, Gaffal E, Bosisio FM, Bechter O, Rambow F, Marine JC, Kastenmüller W, Müller AJ, Tüting T. Kruse B, et al. Among authors: kastenmuller w. Nature. 2023 Jun;618(7967):1033-1040. doi: 10.1038/s41586-023-06199-x. Epub 2023 Jun 14. Nature. 2023. PMID: 37316667 Free PMC article.
Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.
Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T. Bald T, et al. Among authors: kastenmuller w. Nature. 2014 Mar 6;507(7490):109-13. doi: 10.1038/nature13111. Epub 2014 Feb 26. Nature. 2014. PMID: 24572365
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.
Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M. Glodde N, et al. Among authors: kastenmuller w. Immunity. 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012. Immunity. 2017. PMID: 29045907 Free article.
CD4+ T cell help in cancer immunology and immunotherapy.
Borst J, Ahrends T, Bąbała N, Melief CJM, Kastenmüller W. Borst J, et al. Among authors: kastenmuller w. Nat Rev Immunol. 2018 Oct;18(10):635-647. doi: 10.1038/s41577-018-0044-0. Nat Rev Immunol. 2018. PMID: 30057419 Review.
CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity.
Gressier E, Schulte-Schrepping J, Petrov L, Brumhard S, Stubbemann P, Hiller A, Obermayer B, Spitzer J, Kostevc T, Whitney PG, Bachem A, Odainic A, van de Sandt C, Nguyen THO, Ashhurst T, Wilson K, Oates CVL, Gearing LJ, Meischel T, Hochheiser K, Greyer M, Clarke M, Kreutzenbeck M, Gabriel SS, Kastenmüller W, Kurts C, Londrigan SL, Kallies A, Kedzierska K, Hertzog PJ, Latz E, Chen YE, Radford KJ, Chopin M, Schroeder J, Kurth F, Gebhardt T, Sander LE, Sawitzki B, Schultze JL, Schmidt SV, Bedoui S. Gressier E, et al. Among authors: kastenmuller w. Nat Immunol. 2023 Jun;24(6):979-990. doi: 10.1038/s41590-023-01517-x. Epub 2023 May 15. Nat Immunol. 2023. PMID: 37188942
Dendritic cell-targeted vaccines--hope or hype?
Kastenmüller W, Kastenmüller K, Kurts C, Seder RA. Kastenmüller W, et al. Among authors: kastenmuller k. Nat Rev Immunol. 2014 Oct;14(10):705-11. doi: 10.1038/nri3727. Epub 2014 Sep 5. Nat Rev Immunol. 2014. PMID: 25190285 Review.
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.
Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W. Welz M, et al. Among authors: kastenmuller w. Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x. Nat Commun. 2018. PMID: 30442932 Free PMC article.
Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells.
De Giovanni M, Cutillo V, Giladi A, Sala E, Maganuco CG, Medaglia C, Di Lucia P, Bono E, Cristofani C, Consolo E, Giustini L, Fiore A, Eickhoff S, Kastenmüller W, Amit I, Kuka M, Iannacone M. De Giovanni M, et al. Among authors: kastenmuller w. Nat Immunol. 2020 Mar;21(3):321-330. doi: 10.1038/s41590-020-0596-6. Epub 2020 Feb 17. Nat Immunol. 2020. PMID: 32066949 Free PMC article.
MYB orchestrates T cell exhaustion and response to checkpoint inhibition.
Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knöpper K, Utzschneider DT, Nüssing S, Liao Y, Mason T, Torres SV, Wilcox SA, Kanev K, Jarosch S, Leube J, Nutt SL, Zehn D, Parish IA, Kastenmüller W, Shi W, Buchholz VR, Kallies A. Tsui C, et al. Among authors: kastenmuller w. Nature. 2022 Sep;609(7926):354-360. doi: 10.1038/s41586-022-05105-1. Epub 2022 Aug 17. Nature. 2022. PMID: 35978192 Free PMC article.
Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming.
Wu H, Zhao X, Hochrein SM, Eckstein M, Gubert GF, Knöpper K, Mansilla AM, Öner A, Doucet-Ladevèze R, Schmitz W, Ghesquière B, Theurich S, Dudek J, Gasteiger G, Zernecke A, Kobold S, Kastenmüller W, Vaeth M. Wu H, et al. Among authors: kastenmuller w. Nat Commun. 2023 Oct 27;14(1):6858. doi: 10.1038/s41467-023-42634-3. Nat Commun. 2023. PMID: 37891230 Free PMC article.
70 results