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p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP 4th, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C. Moon SH, et al. Among authors: kastenhuber er. Cell. 2019 Jan 24;176(3):564-580.e19. doi: 10.1016/j.cell.2018.11.011. Epub 2018 Dec 20. Cell. 2019. PMID: 30580964 Free PMC article.
Putting p53 in Context.
Kastenhuber ER, Lowe SW. Kastenhuber ER, et al. Cell. 2017 Sep 7;170(6):1062-1078. doi: 10.1016/j.cell.2017.08.028. Cell. 2017. PMID: 28886379 Free PMC article. Review.
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.
Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. Tschaharganeh DF, et al. Among authors: kastenhuber er. Cell. 2014 Jul 31;158(3):579-92. doi: 10.1016/j.cell.2014.05.051. Cell. 2014. PMID: 25083869 Free PMC article.
DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.
Kastenhuber ER, Lalazar G, Houlihan SL, Tschaharganeh DF, Baslan T, Chen CC, Requena D, Tian S, Bosbach B, Wilkinson JE, Simon SM, Lowe SW. Kastenhuber ER, et al. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13076-13084. doi: 10.1073/pnas.1716483114. Epub 2017 Nov 21. Proc Natl Acad Sci U S A. 2017. PMID: 29162699 Free PMC article.
A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1.
Loizou E, Banito A, Livshits G, Ho YJ, Koche RP, Sánchez-Rivera FJ, Mayle A, Chen CC, Kinalis S, Bagger FO, Kastenhuber ER, Durham BH, Lowe SW. Loizou E, et al. Among authors: kastenhuber er. Cancer Discov. 2019 Jul;9(7):962-979. doi: 10.1158/2159-8290.CD-18-1391. Epub 2019 May 8. Cancer Discov. 2019. PMID: 31068365 Free PMC article.
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.
Liu Y, Chen C, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, Levine RL, Mills AA, Lowe SW. Liu Y, et al. Among authors: kastenhuber er. Nature. 2016 Mar 24;531(7595):471-475. doi: 10.1038/nature17157. Epub 2016 Mar 16. Nature. 2016. PMID: 26982726 Free PMC article.
p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer.
Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. Tschaharganeh DF, et al. Among authors: kastenhuber er. Cell. 2016 Jun 2;165(6):1546-1547. doi: 10.1016/j.cell.2016.05.058. Cell. 2016. PMID: 27259155 Free PMC article. No abstract available.
Inducible in vivo genome editing with CRISPR-Cas9.
Dow LE, Fisher J, O'Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW. Dow LE, et al. Among authors: kastenhuber er. Nat Biotechnol. 2015 Apr;33(4):390-394. doi: 10.1038/nbt.3155. Epub 2015 Feb 18. Nat Biotechnol. 2015. PMID: 25690852 Free PMC article.
Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.
Ebbesen SH, Scaltriti M, Bialucha CU, Morse N, Kastenhuber ER, Wen HY, Dow LE, Baselga J, Lowe SW. Ebbesen SH, et al. Among authors: kastenhuber er. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3030-5. doi: 10.1073/pnas.1523693113. Epub 2016 Feb 29. Proc Natl Acad Sci U S A. 2016. PMID: 26929372 Free PMC article.
38 results