Kassab SE - Search Results

1

Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme.

El-Dershaby NH, El-Hawash SA, Kassab SE, Dabees HG, Abdel Moneim AE, Abdel Wahab IA, Abd-Alhaseeb MM, El-Miligy MMM. El-Dershaby NH, et al. Among authors: kassab se. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1737-1751. doi: 10.1080/14756366.2022.2086868. J Enzyme Inhib Med Chem. 2022. PMID: 35707920 Free PMC article.

2

Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities.

Kassab SE, Khedr MA, Ali HI, Abdalla MM. Kassab SE, et al. Eur J Med Chem. 2017 Dec 1;141:306-321. doi: 10.1016/j.ejmech.2017.09.056. Epub 2017 Sep 28. Eur J Med Chem. 2017. PMID: 29031075

3

Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma.

Kassab SE, Mowafy S, Alserw AM, Seliem JA, El-Naggar SM, Omar NN, Awad MM. Kassab SE, et al. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1062-1077. doi: 10.1080/14756366.2019.1613987. J Enzyme Inhib Med Chem. 2019. PMID: 31072216 Free PMC article.

4

Febuxostat-based amides and some derived heterocycles targeting xanthine oxidase and COX inhibition. Synthesis, in vitro and in vivo biological evaluation, molecular modeling and in silico ADMET studies.

Rashad AY, Kassab SE, Daabees HG, Abdel Moneim AE, Rostom SAF. Rashad AY, et al. Among authors: kassab se. Bioorg Chem. 2021 Aug;113:104948. doi: 10.1016/j.bioorg.2021.104948. Epub 2021 Apr 27. Bioorg Chem. 2021. PMID: 34052736

5

Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs.

El-Dershaby NH, El-Hawash SA, Kassab SE, Daabees HG, Abdel Moneim AE, El-Miligy MMM. El-Dershaby NH, et al. Among authors: kassab se. Pharmaceuticals (Basel). 2022 Sep 20;15(10):1165. doi: 10.3390/ph15101165. Pharmaceuticals (Basel). 2022. PMID: 36297278 Free PMC article.

6

Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors.

ElBordiny HS, El-Miligy MM, Kassab SE, Daabees H, Mohamed Ali WA, Abdelhamid Mohamed El-Hawash S. ElBordiny HS, et al. Among authors: kassab se. Eur J Med Chem. 2018 Feb 10;145:594-605. doi: 10.1016/j.ejmech.2018.01.026. Epub 2018 Jan 10. Eur J Med Chem. 2018. PMID: 29339254

7

Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma.

Khodair AI, El-Hallouty SM, Cagle-White B, Abdel Aziz MH, Hanafy MK, Mowafy S, Hamdy NM, Kassab SE. Khodair AI, et al. Among authors: kassab se. Eur J Med Chem. 2024 Feb 5;265:116049. doi: 10.1016/j.ejmech.2023.116049. Epub 2023 Dec 16. Eur J Med Chem. 2024. PMID: 38185054

8

Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents.

Abdel-Atty MM, Farag NA, Kassab SE, Serya RAT, Abouzid KAM. Abdel-Atty MM, et al. Among authors: kassab se. Bioorg Chem. 2014 Dec;57:65-82. doi: 10.1016/j.bioorg.2014.08.006. Epub 2014 Sep 3. Bioorg Chem. 2014. PMID: 25233258

9

Synthesis of 1H-indole-2,3-dione-3-thiosemicarbazone ribonucleosides as antibacterial agents.

Kassab SE, Hegazy GH, Eid NM, Amin KM, El-Gendy AA. Kassab SE, et al. Nucleosides Nucleotides Nucleic Acids. 2010 Jan;29(1):72-80. doi: 10.1080/15257770903459267. Nucleosides Nucleotides Nucleic Acids. 2010. PMID: 20391194

10

A promising anti-cancer and anti-oxidant agents based on the pyrrole and fused pyrrole: synthesis, docking studies and biological evaluation.

Fatahala SS, Shalaby EA, Kassab SE, Mohamed MS. Fatahala SS, et al. Among authors: kassab se. Anticancer Agents Med Chem. 2015;15(4):517-26. doi: 10.2174/1871520615666150105113946. Anticancer Agents Med Chem. 2015. PMID: 25929576

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