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Quantitative Systems Pharmacology: An Exemplar Model-Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development.
Helmlinger G, Sokolov V, Peskov K, Hallow KM, Kosinsky Y, Voronova V, Chu L, Yakovleva T, Azarov I, Kaschek D, Dolgun A, Schmidt H, Boulton DW, Penland RC. Helmlinger G, et al. Among authors: kaschek d. CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):380-395. doi: 10.1002/psp4.12426. Epub 2019 Jun 11. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31087533 Free PMC article. Review.
Efficient simulation of clinical target response surfaces.
Lill D, Kümmel A, Mitov V, Kaschek D, Gobeau N, Schmidt H, Timmer J. Lill D, et al. Among authors: kaschek d. CPT Pharmacometrics Syst Pharmacol. 2022 Apr;11(4):512-523. doi: 10.1002/psp4.12779. Epub 2022 Mar 11. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35199969 Free PMC article.
Lessons learned from quantitative dynamical modeling in systems biology.
Raue A, Schilling M, Bachmann J, Matteson A, Schelker M, Kaschek D, Hug S, Kreutz C, Harms BD, Theis FJ, Klingmüller U, Timmer J. Raue A, et al. Among authors: kaschek d. PLoS One. 2013 Sep 30;8(9):e74335. doi: 10.1371/journal.pone.0074335. eCollection 2013. PLoS One. 2013. PMID: 24098642 Free PMC article.
Profile likelihood in systems biology.
Kreutz C, Raue A, Kaschek D, Timmer J. Kreutz C, et al. Among authors: kaschek d. FEBS J. 2013 Jun;280(11):2564-71. doi: 10.1111/febs.12276. Epub 2013 May 9. FEBS J. 2013. PMID: 23581573 Free article. Review.
Driving the Model to Its Limit: Profile Likelihood Based Model Reduction.
Maiwald T, Hass H, Steiert B, Vanlier J, Engesser R, Raue A, Kipkeew F, Bock HH, Kaschek D, Kreutz C, Timmer J. Maiwald T, et al. Among authors: kaschek d. PLoS One. 2016 Sep 2;11(9):e0162366. doi: 10.1371/journal.pone.0162366. eCollection 2016. PLoS One. 2016. PMID: 27588423 Free PMC article.
Model-based extension of high-throughput to high-content data.
Pfeifer AC, Kaschek D, Bachmann J, Klingmüller U, Timmer J. Pfeifer AC, et al. Among authors: kaschek d. BMC Syst Biol. 2010 Aug 5;4:106. doi: 10.1186/1752-0509-4-106. BMC Syst Biol. 2010. PMID: 20687942 Free PMC article.
Semi-automatic determination of cell surface areas used in systems biology.
Morath V, Keuper M, Rodriguez-Franco M, Deswal S, Fiala G, Blumenthal B, Kaschek D, Timmer J, Neuhaus G, Ehl S, Ronneberger O, Schamel WW. Morath V, et al. Among authors: kaschek d. Front Biosci (Elite Ed). 2013 Jan 1;5(2):533-45. doi: 10.2741/e635. Front Biosci (Elite Ed). 2013. PMID: 23277009 Free article.
21 results