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Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys.
Nickerson-Nutter C, Tchistiakova L, Seth NP, Kasaian M, Sibley B, Olland S, Zollner R, Brady WA, Mohler KM, Baum P, Wahl A, Herber D, Vugmeyster Y, Wensel D, Wolfman NM, Gill D, Collins M, Dunussi-Joannopoulos K. Nickerson-Nutter C, et al. Among authors: kasaian m. Rheumatology (Oxford). 2011 Jun;50(6):1033-44. doi: 10.1093/rheumatology/keq423. Epub 2011 Jan 21. Rheumatology (Oxford). 2011. PMID: 21258049 Free PMC article.
Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys.
Kasaian MT, Tan XY, Jin M, Fitz L, Marquette K, Wood N, Cook TA, Lee J, Widom A, Agostinelli R, Bree A, Schlerman FJ, Olland S, Wadanoli M, Sypek J, Gill D, Goldman SJ, Tchistiakova L. Kasaian MT, et al. J Pharmacol Exp Ther. 2008 Jun;325(3):882-92. doi: 10.1124/jpet.108.136515. Epub 2008 Mar 12. J Pharmacol Exp Ther. 2008. PMID: 18337474
IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys.
Bree A, Schlerman FJ, Wadanoli M, Tchistiakova L, Marquette K, Tan XY, Jacobson BA, Widom A, Cook TA, Wood N, Vunnum S, Krykbaev R, Xu X, Donaldson DD, Goldman SJ, Sypek J, Kasaian MT. Bree A, et al. Among authors: kasaian mt. J Allergy Clin Immunol. 2007 May;119(5):1251-7. doi: 10.1016/j.jaci.2007.02.009. Epub 2007 Mar 26. J Allergy Clin Immunol. 2007. PMID: 17379289
IL-21 effects on human IgE production in response to IL-4 or IL-13.
Wood N, Bourque K, Donaldson DD, Collins M, Vercelli D, Goldman SJ, Kasaian MT. Wood N, et al. Among authors: kasaian mt. Cell Immunol. 2004 Sep-Oct;231(1-2):133-45. doi: 10.1016/j.cellimm.2005.01.001. Epub 2005 Feb 9. Cell Immunol. 2004. PMID: 15919378
Efficacy of IL-13 neutralization in a sheep model of experimental asthma.
Kasaian MT, Donaldson DD, Tchistiakova L, Marquette K, Tan XY, Ahmed A, Jacobson BA, Widom A, Cook TA, Xu X, Barry AB, Goldman SJ, Abraham WM. Kasaian MT, et al. Am J Respir Cell Mol Biol. 2007 Mar;36(3):368-76. doi: 10.1165/rcmb.2006-0244OC. Epub 2006 Oct 5. Am J Respir Cell Mol Biol. 2007. PMID: 17023688
65 results