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The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation.
Genes Dev. 2020 Apr 1;34(7-8):495-510. doi: 10.1101/gad.333617.119. Epub 2020 Mar 5.
Genes Dev. 2020.
PMID: 32139423
Free PMC article.
Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity.
Löffler MC, Mayer AE, Trujillo Viera J, Loza Valdes A, El-Merahbi R, Ade CP, Karwen T, Schmitz W, Slotta A, Erk M, Janaki-Raman S, Matesanz N, Torres JL, Marcos M, Sabio G, Eilers M, Schulze A, Sumara G.
Löffler MC, et al. Among authors: karwen t.
EMBO J. 2018 Nov 15;37(22):e99182. doi: 10.15252/embj.201899182. Epub 2018 Nov 2.
EMBO J. 2018.
PMID: 30389661
Free PMC article.
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Targeting ERK3/MK5 complex for treatment of obesity and diabetes.
Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera JT, Karwen T, Noh M, Löffler MC, Romero-Becerra R, Torres JL, Marcos M, Sabio G, Wojda U, Sumara G.
Loza-Valdes A, et al. Among authors: karwen t.
Biochem Biophys Res Commun. 2022 Jul 5;612:119-125. doi: 10.1016/j.bbrc.2022.04.070. Epub 2022 Apr 27.
Biochem Biophys Res Commun. 2022.
PMID: 35523049
Free article.
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Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.
Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G.
Trujillo-Viera J, et al. Among authors: karwen t.
EMBO Mol Med. 2021 May 7;13(5):e13548. doi: 10.15252/emmm.202013548. Epub 2021 May 5.
EMBO Mol Med. 2021.
PMID: 33949105
Free PMC article.
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Platelet-derived lipids promote insulin secretion of pancreatic β cells.
Karwen T, Kolczynska-Matysiak K, Gross C, Löffler MC, Friedrich M, Loza-Valdes A, Schmitz W, Wit M, Dziaczkowski F, Belykh A, Trujillo-Viera J, El-Merahbi R, Deppermann C, Nawaz S, Hastoy B, Demczuk A, Erk M, Wieckowski MR, Rorsman P, Heinze KG, Stegner D, Nieswandt B, Sumara G.
Karwen T, et al.
EMBO Mol Med. 2023 Sep 11;15(9):e16858. doi: 10.15252/emmm.202216858. Epub 2023 Jul 25.
EMBO Mol Med. 2023.
PMID: 37490001
Free PMC article.
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