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Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR Agonists.
Pérez-Jeldres T, Tyler CJ, Boyer JD, Karuppuchamy T, Yarur A, Giles DA, Yeasmin S, Lundborg L, Sandborn WJ, Patel DR, Rivera-Nieves J. Pérez-Jeldres T, et al. Among authors: karuppuchamy t. Front Pharmacol. 2019 Mar 13;10:212. doi: 10.3389/fphar.2019.00212. eCollection 2019. Front Pharmacol. 2019. PMID: 30930775 Free PMC article. Review.
Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease.
Tyler CJ, Pérez-Jeldres T, Ehinger E, Capaldo B, Karuppuchamy T, Boyer JD, Patel D, Dulai P, Boland BS, Lannigan J, Eckmann L, Ernst PB, Sandborn WJ, Ho SB, Rivera-Nieves J. Tyler CJ, et al. Among authors: karuppuchamy t. Inflamm Bowel Dis. 2018 Oct 12;24(11):2366-2376. doi: 10.1093/ibd/izy214. Inflamm Bowel Dis. 2018. PMID: 29889233 Free PMC article.
Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.
Karuppuchamy T, Behrens EH, González-Cabrera P, Sarkisyan G, Gima L, Boyer JD, Bamias G, Jedlicka P, Veny M, Clark D, Peach R, Scott F, Rosen H, Rivera-Nieves J. Karuppuchamy T, et al. Mucosal Immunol. 2017 Jan;10(1):162-171. doi: 10.1038/mi.2016.35. Epub 2016 Apr 6. Mucosal Immunol. 2017. PMID: 27049060 Free PMC article.
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. Takemura N, et al. Among authors: karuppuchamy t. Nat Commun. 2014 Mar 18;5:3492. doi: 10.1038/ncomms4492. Nat Commun. 2014. PMID: 24637670 Free PMC article.
Bone-protective Functions of Netrin 1 Protein.
Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S. Maruyama K, et al. Among authors: karuppuchamy t. J Biol Chem. 2016 Nov 11;291(46):23854-23868. doi: 10.1074/jbc.M116.738518. Epub 2016 Sep 28. J Biol Chem. 2016. PMID: 27681594 Free PMC article.