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The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B. Sala Frigerio C, et al. Among authors: karran e. Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099. Cell Rep. 2019. PMID: 31018141 Free PMC article.
The Cellular Phase of Alzheimer's Disease.
De Strooper B, Karran E. De Strooper B, et al. Among authors: karran e. Cell. 2016 Feb 11;164(4):603-15. doi: 10.1016/j.cell.2015.12.056. Cell. 2016. PMID: 26871627 Free article. Review.
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. Serneels L, et al. Among authors: karran e. Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19. Science. 2009. PMID: 19299585 Free PMC article.
Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.
Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill LM, Gonzalez-Rivera I, Buchanan F, Prescott AR, Faust D, Fox S, Brownlees J, Taylor D, Perry VH, Nuthall H, Atkinson PJ, Karran E, Routledge C, Gomez-Nicola D. Obst J, et al. Among authors: karran e. Front Immunol. 2020 Oct 8;11:579000. doi: 10.3389/fimmu.2020.579000. eCollection 2020. Front Immunol. 2020. PMID: 33162994 Free PMC article.
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.
Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B. Chávez-Gutiérrez L, et al. Among authors: karran e. EMBO J. 2012 May 16;31(10):2261-74. doi: 10.1038/emboj.2012.79. Epub 2012 Apr 13. EMBO J. 2012. PMID: 22505025 Free PMC article.
127 results