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Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia.
Cells. 2022 Jan 18;11(3):313. doi: 10.3390/cells11030313.
Cells. 2022.
PMID: 35159123
Free PMC article.
Review.
Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver.
Hassani-Nezhad-Gashti F, Rysä J, Kummu O, Näpänkangas J, Buler M, Karpale M, Hukkanen J, Hakkola J.
Hassani-Nezhad-Gashti F, et al. Among authors: karpale m.
Biochem Pharmacol. 2018 Feb;148:253-264. doi: 10.1016/j.bcp.2018.01.001. Epub 2018 Jan 5.
Biochem Pharmacol. 2018.
PMID: 29309761
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Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism.
Karpale M, Käräjämäki AJ, Kummu O, Gylling H, Hyötyläinen T, Orešič M, Tolonen A, Hautajärvi H, Savolainen MJ, Ala-Korpela M, Hukkanen J, Hakkola J.
Karpale M, et al.
Br J Pharmacol. 2021 Jun;178(12):2461-2481. doi: 10.1111/bph.15433. Epub 2021 May 14.
Br J Pharmacol. 2021.
PMID: 33687065
Free article.
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Nutritional status modifies pregnane X receptor regulated transcriptome.
Hassani-Nezhad-Gashti F, Kummu O, Karpale M, Rysä J, Hakkola J.
Hassani-Nezhad-Gashti F, et al. Among authors: karpale m.
Sci Rep. 2019 Nov 13;9(1):16728. doi: 10.1038/s41598-019-53101-9.
Sci Rep. 2019.
PMID: 31723190
Free PMC article.
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Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes.
Aatsinki SM, Elkhwanky MS, Kummu O, Karpale M, Buler M, Viitala P, Rinne V, Mutikainen M, Tavi P, Franko A, Wiesner RJ, Chambers KT, Finck BN, Hakkola J.
Aatsinki SM, et al. Among authors: karpale m.
Diabetes. 2019 May;68(5):918-931. doi: 10.2337/db18-1050. Epub 2019 Mar 4.
Diabetes. 2019.
PMID: 30833469
Free PMC article.
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Hemoglobin levels are associated with retinal vascular caliber in a middle-aged birth cohort.
Sakko S, Karpale M, Tapio J, Leppänen I, Ahokas O, Saarela V, Liinamaa MJ, Koivunen P.
Sakko S, et al. Among authors: karpale m.
Sci Rep. 2024 Apr 20;14(1):9092. doi: 10.1038/s41598-024-59688-y.
Sci Rep. 2024.
PMID: 38643302
Free PMC article.
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Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.
Ala-Nisula T, Halmetoja R, Leinonen H, Kurkela M, Lipponen HR, Sakko S, Karpale M, Salo AM, Sissala N, Röning T, Raza GS, Mäkelä KA, Thevenot J, Herzig KH, Serpi R, Myllyharju J, Tanila H, Koivunen P, Dimova EY.
Ala-Nisula T, et al. Among authors: karpale m.
Pflugers Arch. 2024 Feb 24. doi: 10.1007/s00424-024-02920-5. Online ahead of print.
Pflugers Arch. 2024.
PMID: 38396259
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Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice.
Karpale M, Kummu O, Kärkkäinen O, Lehtonen M, Näpänkangas J, Herfurth UM, Braeuning A, Rysä J, Hakkola J.
Karpale M, et al.
Mol Metab. 2023 Oct;76:101779. doi: 10.1016/j.molmet.2023.101779. Epub 2023 Jul 17.
Mol Metab. 2023.
PMID: 37467962
Free PMC article.
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