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Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: karlen a. Nat Rev Chem. 2021 Oct;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 37118182 Review.
Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.
Grinkevich VV, Vema A, Fawkner K, Issaeva N, Andreotti V, Dickinson ER, Hedström E, Spinnler C, Inga A, Larsson LG, Karlén A, Wilhelm M, Barran PE, Okorokov AL, Selivanova G, Zawacka-Pankau JE. Grinkevich VV, et al. Among authors: karlen a. Front Mol Biosci. 2022 Jun 1;9:823195. doi: 10.3389/fmolb.2022.823195. eCollection 2022. Front Mol Biosci. 2022. PMID: 35720128 Free PMC article.
A frame shifted disulfide bridged analogue of angiotensin II.
Schmidt B, Kühn C, Ehlert DK, Lindeberg G, Lindman S, Karlén A, Hallberg A. Schmidt B, et al. Among authors: karlen a. Bioorg Med Chem. 2003 Mar 20;11(6):985-90. doi: 10.1016/s0968-0896(02)00517-5. Bioorg Med Chem. 2003. PMID: 12614883
138 results