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Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: karlen a. Nat Rev Chem. 2021;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 34426795 Free PMC article. Review.
Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: karlen a. Nat Rev Chem. 2021 Oct;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 37118182 Review.
Discovery and preclinical development of new antibiotics.
Hughes D, Karlén A. Hughes D, et al. Among authors: karlen a. Ups J Med Sci. 2014 May;119(2):162-9. doi: 10.3109/03009734.2014.896437. Epub 2014 Mar 19. Ups J Med Sci. 2014. PMID: 24646082 Free PMC article. Review.
The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance.
Kostyanev T, Bonten MJ, O'Brien S, Steel H, Ross S, François B, Tacconelli E, Winterhalter M, Stavenger RA, Karlén A, Harbarth S, Hackett J, Jafri HS, Vuong C, MacGowan A, Witschi A, Angyalosi G, Elborn JS, deWinter R, Goossens H. Kostyanev T, et al. Among authors: karlen a. J Antimicrob Chemother. 2016 Feb;71(2):290-5. doi: 10.1093/jac/dkv339. Epub 2015 Nov 15. J Antimicrob Chemother. 2016. PMID: 26568581 Review.
The global preclinical antibacterial pipeline.
Theuretzbacher U, Outterson K, Engel A, Karlén A. Theuretzbacher U, et al. Among authors: karlen a. Nat Rev Microbiol. 2020 May;18(5):275-285. doi: 10.1038/s41579-019-0288-0. Epub 2019 Nov 19. Nat Rev Microbiol. 2020. PMID: 31745331 Free PMC article. Review.
Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
Nordqvist A, Björkelid C, Andaloussi M, Jansson AM, Mowbray SL, Karlén A, Larhed M. Nordqvist A, et al. Among authors: karlen a. J Org Chem. 2011 Nov 4;76(21):8986-98. doi: 10.1021/jo201715x. Epub 2011 Oct 7. J Org Chem. 2011. PMID: 21936546 Free PMC article.
138 results