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SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K. Yoshizawa T, et al. Among authors: karim mf. Cell Metab. 2014 Apr 1;19(4):712-21. doi: 10.1016/j.cmet.2014.03.006. Cell Metab. 2014. PMID: 24703702 Free article.
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K. Korogi W, et al. Among authors: karim mf. Biochem Biophys Res Commun. 2018 Feb 2:S0006-291X(18)30144-X. doi: 10.1016/j.bbrc.2018.01.129. Online ahead of print. Biochem Biophys Res Commun. 2018. PMID: 29402405
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K. Fukuda M, et al. Among authors: karim mf. Nat Commun. 2018 Jul 19;9(1):2833. doi: 10.1038/s41467-018-05187-4. Nat Commun. 2018. PMID: 30026585 Free PMC article.
Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K. Sato Y, et al. Among authors: karim mf. J Biol Chem. 2012 Jun 29;287(27):23236-45. doi: 10.1074/jbc.M112.368779. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22589549 Free PMC article.
43 results