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Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention.
Mol Pharm. 2005 Jul-Aug;2(4):312-8. doi: 10.1021/mp050023q.
Mol Pharm. 2005.
PMID: 16053334
Review.
Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition.
Kaminskas LM, Boyd BJ, Karellas P, Henderson SA, Giannis MP, Krippner GY, Porter CJ.
Kaminskas LM, et al. Among authors: karellas p.
Mol Pharm. 2007 Nov-Dec;4(6):949-61. doi: 10.1021/mp070047s. Epub 2007 Oct 23.
Mol Pharm. 2007.
PMID: 17953445
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Structure activity relationship of dendrimer microbicides with dual action antiviral activity.
Tyssen D, Henderson SA, Johnson A, Sterjovski J, Moore K, La J, Zanin M, Sonza S, Karellas P, Giannis MP, Krippner G, Wesselingh S, McCarthy T, Gorry PR, Ramsland PA, Cone R, Paull JR, Lewis GR, Tachedjian G.
Tyssen D, et al. Among authors: karellas p.
PLoS One. 2010 Aug 23;5(8):e12309. doi: 10.1371/journal.pone.0012309.
PLoS One. 2010.
PMID: 20808791
Free PMC article.
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Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats.
Boyd BJ, Kaminskas LM, Karellas P, Krippner G, Lessene R, Porter CJ.
Boyd BJ, et al. Among authors: karellas p.
Mol Pharm. 2006 Sep-Oct;3(5):614-27. doi: 10.1021/mp060032e.
Mol Pharm. 2006.
PMID: 17009860
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The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of PEGylated poly l-lysine dendrimers.
Kaminskas LM, Boyd BJ, Karellas P, Krippner GY, Lessene R, Kelly B, Porter CJ.
Kaminskas LM, et al. Among authors: karellas p.
Mol Pharm. 2008 May-Jun;5(3):449-63. doi: 10.1021/mp7001208. Epub 2008 Apr 5.
Mol Pharm. 2008.
PMID: 18393438
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PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats.
Kaminskas LM, Kota J, McLeod VM, Kelly BD, Karellas P, Porter CJ.
Kaminskas LM, et al. Among authors: karellas p.
J Control Release. 2009 Dec 3;140(2):108-16. doi: 10.1016/j.jconrel.2009.08.005. Epub 2009 Aug 15.
J Control Release. 2009.
PMID: 19686787
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Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands.
Karellas P, McNaughton M, Baker SP, Scammells PJ.
Karellas P, et al.
J Med Chem. 2008 Oct 9;51(19):6128-37. doi: 10.1021/jm800613s. Epub 2008 Sep 11.
J Med Chem. 2008.
PMID: 18783211
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