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Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists.
Barrow JC, Nantermet PG, Selnick HG, Glass KL, Ngo PL, Young MB, Pellicore JM, Breslin MJ, Hutchinson JH, Freidinger RM, Condra C, Karczewski J, Bednar RA, Gaul SL, Stern A, Gould R, Connolly TM. Barrow JC, et al. Among authors: karczewski j. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2691-6. doi: 10.1016/s0960-894x(01)00538-8. Bioorg Med Chem Lett. 2001. PMID: 11591503
Functional and pharmacological properties of canine ERG potassium channels.
Wang J, Della Penna K, Wang H, Karczewski J, Connolly TM, Koblan KS, Bennett PB, Salata JJ. Wang J, et al. Among authors: karczewski j. Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H256-67. doi: 10.1152/ajpheart.00220.2002. Epub 2002 Oct 3. Am J Physiol Heart Circ Physiol. 2003. PMID: 12388285 Free article.
Synthesis of the first sulfur-35-labeled hERG radioligand.
Raab CE, Butcher JW, Connolly TM, Karczewski J, Yu NX, Staskiewicz SJ, Liverton N, Dean DC, Melillo DG. Raab CE, et al. Among authors: karczewski j. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1692-5. doi: 10.1016/j.bmcl.2005.12.021. Epub 2006 Jan 11. Bioorg Med Chem Lett. 2006. PMID: 16377185
The interaction of disagregin with the platelet fibrinogen receptor, glycoprotein IIb-IIIa.
Karczewski J, Connolly TM. Karczewski J, et al. Biochem Biophys Res Commun. 1997 Dec 29;241(3):744-8. doi: 10.1006/bbrc.1997.7881. Biochem Biophys Res Commun. 1997. PMID: 9434779
Disagregin, a 6 kDa protein isolated from salivary glands of the tick Ornithodoros Moubata, is a potent and selective inhibitor of fibrinogen dependent platelet aggregation and of the adhesion of platelets to fibrinogen (Karczewski et al. (1994) J. Biol. Chem. 269, …
Disagregin, a 6 kDa protein isolated from salivary glands of the tick Ornithodoros Moubata, is a potent and selective inhibitor of fibrinoge …
Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).
Nantermet PG, Barrow JC, Lundell GF, Pellicore JM, Rittle KE, Young M, Freidinger RM, Connolly TM, Condra C, Karczewski J, Bednar RA, Gaul SL, Gould RJ, Prendergast K, Selnick HG. Nantermet PG, et al. Among authors: karczewski j. Bioorg Med Chem Lett. 2002 Feb 11;12(3):319-23. doi: 10.1016/s0960-894x(01)00745-4. Bioorg Med Chem Lett. 2002. PMID: 11814787
204 results