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PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma.
Ganci F, Pulito C, Valsoni S, Sacconi A, Turco C, Vahabi M, Manciocco V, Mazza EMC, Meens J, Karamboulas C, Nichols AC, Covello R, Pellini R, Spriano G, Sanguineti G, Muti P, Bicciato S, Ailles L, Strano S, Fontemaggi G, Blandino G. Ganci F, et al. Among authors: karamboulas c. Clin Cancer Res. 2020 Jun 15;26(12):2956-2971. doi: 10.1158/1078-0432.CCR-19-2485. Epub 2020 Jan 22. Clin Cancer Res. 2020. PMID: 31969334
Tumor-initiating cells are rare in many human tumors.
Ishizawa K, Rasheed ZA, Karisch R, Wang Q, Kowalski J, Susky E, Pereira K, Karamboulas C, Moghal N, Rajeshkumar NV, Hidalgo M, Tsao M, Ailles L, Waddell TK, Maitra A, Neel BG, Matsui W. Ishizawa K, et al. Among authors: karamboulas c. Cell Stem Cell. 2010 Sep 3;7(3):279-82. doi: 10.1016/j.stem.2010.08.009. Cell Stem Cell. 2010. PMID: 20804964 Free PMC article.
CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma.
Murillo-Sauca O, Chung MK, Shin JH, Karamboulas C, Kwok S, Jung YH, Oakley R, Tysome JR, Farnebo LO, Kaplan MJ, Sirjani D, Divi V, Holsinger FC, Tomeh C, Nichols A, Le QT, Colevas AD, Kong CS, Uppaluri R, Lewis JS Jr, Ailles LE, Sunwoo JB. Murillo-Sauca O, et al. Among authors: karamboulas c. Oncotarget. 2014 Aug 30;5(16):6854-66. doi: 10.18632/oncotarget.2269. Oncotarget. 2014. PMID: 25149537 Free PMC article.
Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.
Papillon-Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, Stecho W, Howlett CJ, Mymryk JS, Barrett JW, Nichols AC, Allis CD, Majewski J, Jabado N. Papillon-Cavanagh S, et al. Among authors: karamboulas c. Nat Genet. 2017 Feb;49(2):180-185. doi: 10.1038/ng.3757. Epub 2017 Jan 9. Nat Genet. 2017. PMID: 28067913 Free PMC article.
Development and Validation of an Oral Cavity Cancer Outcomes Prediction Score Incorporating Patient-Derived Xenograft Engraftment.
Id Said B, Ailles L, Karamboulas C, Meens J, Huang SH, Xu W, Keshavarzi S, Bratman SV, Cho BCJ, Giuliani M, Hahn E, Kim J, O'Sullivan B, Ringash J, Waldron J, Spreafico A, de Almeida JR, Chepeha DB, Irish JC, Goldstein DP, Hope A, Hosni A. Id Said B, et al. Among authors: karamboulas c. JAMA Otolaryngol Head Neck Surg. 2022 Apr 1;148(4):342-349. doi: 10.1001/jamaoto.2022.0003. JAMA Otolaryngol Head Neck Surg. 2022. PMID: 35238880 Free PMC article.
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