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A microengineered Brain-Chip to model neuroinflammation in humans.
Pediaditakis I, Kodella KR, Manatakis DV, Le CY, Barthakur S, Sorets A, Gravanis A, Ewart L, Rubin LL, Manolakos ES, Hinojosa CD, Karalis K. Pediaditakis I, et al. Among authors: karalis k. iScience. 2022 Jul 21;25(8):104813. doi: 10.1016/j.isci.2022.104813. eCollection 2022 Aug 19. iScience. 2022. PMID: 35982785 Free PMC article.
Modeling alcohol-associated liver disease in a human Liver-Chip.
Nawroth JC, Petropolis DB, Manatakis DV, Maulana TI, Burchett G, Schlünder K, Witt A, Shukla A, Kodella K, Ronxhi J, Kulkarni G, Hamilton G, Seki E, Lu S, Karalis KC. Nawroth JC, et al. Among authors: karalis kc. Cell Rep. 2021 Jul 20;36(3):109393. doi: 10.1016/j.celrep.2021.109393. Cell Rep. 2021. PMID: 34289365 Free PMC article.
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.
Kasendra M, Luc R, Yin J, Manatakis DV, Kulkarni G, Lucchesi C, Sliz J, Apostolou A, Sunuwar L, Obrigewitch J, Jang KJ, Hamilton GA, Donowitz M, Karalis K. Kasendra M, et al. Among authors: karalis k. Elife. 2020 Jan 14;9:e50135. doi: 10.7554/eLife.50135. Elife. 2020. PMID: 31933478 Free PMC article.
A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability.
Apostolou A, Panchakshari RA, Banerjee A, Manatakis DV, Paraskevopoulou MD, Luc R, Abu-Ali G, Dimitriou A, Lucchesi C, Kulkarni G, Maulana TI, Kasendra M, Kerns JS, Bleck B, Ewart L, Manolakos ES, Hamilton GA, Giallourakis C, Karalis K. Apostolou A, et al. Among authors: karalis k. Cell Mol Gastroenterol Hepatol. 2021;12(5):1719-1741. doi: 10.1016/j.jcmgh.2021.07.004. Epub 2021 Jul 17. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34284165 Free PMC article.
Reproducing human and cross-species drug toxicities using a Liver-Chip.
Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA. Jang KJ, et al. Among authors: karalis k. Sci Transl Med. 2019 Nov 6;11(517):eaax5516. doi: 10.1126/scitranslmed.aax5516. Sci Transl Med. 2019. PMID: 31694927
Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.
Kerns SJ, Belgur C, Petropolis D, Kanellias M, Barrile R, Sam J, Weinzierl T, Fauti T, Freimoser-Grundschober A, Eckmann J, Hage C, Geiger M, Ng PR, Tien-Street W, Manatakis DV, Micallef V, Gerard R, Bscheider M, Breous-Nystrom E, Schneider A, Giusti AM, Bertinetti-Lapatki C, Grant HS, Roth AB, Hamilton GA, Singer T, Karalis K, Moisan A, Bruenker P, Klein C, Bacac M, Gjorevski N, Cabon L. Kerns SJ, et al. Among authors: karalis k. Elife. 2021 Aug 11;10:e67106. doi: 10.7554/eLife.67106. Elife. 2021. PMID: 34378534 Free PMC article.
Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems.
Barrile R, van der Meer AD, Park H, Fraser JP, Simic D, Teng F, Conegliano D, Nguyen J, Jain A, Zhou M, Karalis K, Ingber DE, Hamilton GA, Otieno MA. Barrile R, et al. Among authors: karalis k. Clin Pharmacol Ther. 2018 Dec;104(6):1240-1248. doi: 10.1002/cpt.1054. Epub 2018 Apr 30. Clin Pharmacol Ther. 2018. PMID: 29484632
113 results