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Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.
Kasendra M, Luc R, Yin J, Manatakis DV, Kulkarni G, Lucchesi C, Sliz J, Apostolou A, Sunuwar L, Obrigewitch J, Jang KJ, Hamilton GA, Donowitz M, Karalis K. Kasendra M, et al. Among authors: karalis k. Elife. 2020 Jan 14;9:e50135. doi: 10.7554/eLife.50135. Elife. 2020. PMID: 31933478 Free PMC article.
A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability.
Apostolou A, Panchakshari RA, Banerjee A, Manatakis DV, Paraskevopoulou MD, Luc R, Abu-Ali G, Dimitriou A, Lucchesi C, Kulkarni G, Maulana TI, Kasendra M, Kerns JS, Bleck B, Ewart L, Manolakos ES, Hamilton GA, Giallourakis C, Karalis K. Apostolou A, et al. Among authors: karalis k. Cell Mol Gastroenterol Hepatol. 2021;12(5):1719-1741. doi: 10.1016/j.jcmgh.2021.07.004. Epub 2021 Jul 17. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34284165 Free PMC article.
Reproducing human and cross-species drug toxicities using a Liver-Chip.
Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA. Jang KJ, et al. Among authors: karalis k. Sci Transl Med. 2019 Nov 6;11(517):eaax5516. doi: 10.1126/scitranslmed.aax5516. Sci Transl Med. 2019. PMID: 31694927
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip.
Yin J, Sunuwar L, Kasendra M, Yu H, Tse CM, Talbot CC Jr, Boronina T, Cole R, Karalis K, Donowitz M. Yin J, et al. Among authors: karalis k. Am J Physiol Gastrointest Liver Physiol. 2021 Mar 1;320(3):G258-G271. doi: 10.1152/ajpgi.00282.2020. Epub 2020 Oct 14. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 33074011 Free PMC article.
Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.
Kerns SJ, Belgur C, Petropolis D, Kanellias M, Barrile R, Sam J, Weinzierl T, Fauti T, Freimoser-Grundschober A, Eckmann J, Hage C, Geiger M, Ng PR, Tien-Street W, Manatakis DV, Micallef V, Gerard R, Bscheider M, Breous-Nystrom E, Schneider A, Giusti AM, Bertinetti-Lapatki C, Grant HS, Roth AB, Hamilton GA, Singer T, Karalis K, Moisan A, Bruenker P, Klein C, Bacac M, Gjorevski N, Cabon L. Kerns SJ, et al. Among authors: karalis k. Elife. 2021 Aug 11;10:e67106. doi: 10.7554/eLife.67106. Elife. 2021. PMID: 34378534 Free PMC article.
113 results