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Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3.
Weinmüller M, Rechenmacher F, Kiran Marelli U, Reichart F, Kapp TG, Räder AFB, Di Leva FS, Marinelli L, Novellino E, Muñoz-Félix JM, Hodivala-Dilke K, Schumacher A, Fanous J, Gilon C, Hoffman A, Kessler H. Weinmüller M, et al. Among authors: kapp tg. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16405-16409. doi: 10.1002/anie.201709709. Epub 2017 Nov 23. Angew Chem Int Ed Engl. 2017. PMID: 29072809
αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating.
Mas-Moruno C, Fraioli R, Rechenmacher F, Neubauer S, Kapp TG, Kessler H. Mas-Moruno C, et al. Among authors: kapp tg. Angew Chem Int Ed Engl. 2016 Jun 13;55(25):7048-67. doi: 10.1002/anie.201509782. Epub 2016 Jun 3. Angew Chem Int Ed Engl. 2016. PMID: 27258759 Review.
Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide.
Reichart F, Maltsev OV, Kapp TG, Räder AFB, Weinmüller M, Marelli UK, Notni J, Wurzer A, Beck R, Wester HJ, Steiger K, Di Maro S, Di Leva FS, Marinelli L, Nieberler M, Reuning U, Schwaiger M, Kessler H. Reichart F, et al. Among authors: kapp tg. J Med Chem. 2019 Feb 28;62(4):2024-2037. doi: 10.1021/acs.jmedchem.8b01588. Epub 2019 Feb 6. J Med Chem. 2019. PMID: 30657681
Integrin modulators: a patent review.
Kapp TG, Rechenmacher F, Sobahi TR, Kessler H. Kapp TG, et al. Expert Opin Ther Pat. 2013 Oct;23(10):1273-95. doi: 10.1517/13543776.2013.818133. Expert Opin Ther Pat. 2013. PMID: 24050747 Review.
Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells.
Ray AM, Schaffner F, Janouskova H, Noulet F, Rognan D, Lelong-Rebel I, Choulier L, Blandin AF, Lehmann M, Martin S, Kapp T, Neubauer S, Rechenmacher F, Kessler H, Dontenwill M. Ray AM, et al. Biochim Biophys Acta. 2014 Sep;1840(9):2978-87. doi: 10.1016/j.bbagen.2014.04.024. Epub 2014 May 5. Biochim Biophys Acta. 2014. PMID: 24810979
21 results