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Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: kapoor tm. J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22. J Am Chem Soc. 2024. PMID: 38134034
Site-specific chemistry on the microtubule polymer.
Kleiner RE, Ti SC, Kapoor TM. Kleiner RE, et al. Among authors: kapoor tm. J Am Chem Soc. 2013 Aug 28;135(34):12520-3. doi: 10.1021/ja405199h. Epub 2013 Aug 15. J Am Chem Soc. 2013. PMID: 23930594 Free PMC article.
136 results