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Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+.
Kapoor M, Mukhi PL, Surolia N, Suguna K, Surolia A. Kapoor M, et al. Biochem J. 2004 Aug 1;381(Pt 3):725-33. doi: 10.1042/BJ20040228. Biochem J. 2004. PMID: 15125687 Free PMC article.
The binding constants determined for crotonoyl-CoA and NADH were 1.6x10(4) M(-1) and 1.9x10(4) M(-1) respectively. Triclosan, which has recently been demonstrated as a potent antimalarial agent, bound to the enzyme with a binding constant of 1.08x10(5) M(-1). …
The binding constants determined for crotonoyl-CoA and NADH were 1.6x10(4) M(-1) and 1.9x10(4) M(-1) respectively. Triclosan, …
783 results