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Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1361-1369. doi: 10.1073/pnas.1812266115. Epub 2018 Dec 13.
Proc Natl Acad Sci U S A. 2019.
PMID: 30545915
Free PMC article.
Clinical Trial.
The role of IL-1β in the early tumor cell-induced angiogenic response.
Carmi Y, Dotan S, Rider P, Kaplanov I, White MR, Baron R, Abutbul S, Huszar M, Dinarello CA, Apte RN, Voronov E.
Carmi Y, et al. Among authors: kaplanov i.
J Immunol. 2013 Apr 1;190(7):3500-9. doi: 10.4049/jimmunol.1202769. Epub 2013 Mar 8.
J Immunol. 2013.
PMID: 23475218
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Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice.
Bersudsky M, Luski L, Fishman D, White RM, Ziv-Sokolovskaya N, Dotan S, Rider P, Kaplanov I, Aychek T, Dinarello CA, Apte RN, Voronov E.
Bersudsky M, et al. Among authors: kaplanov i.
Gut. 2014 Apr;63(4):598-609. doi: 10.1136/gutjnl-2012-303329. Epub 2013 Jun 21.
Gut. 2014.
PMID: 23793223
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Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment.
Voronov E, Dotan S, Krelin Y, Song X, Elkabets M, Carmi Y, Rider P, Idan Cohen, Romzova M, Kaplanov I, Apte RN.
Voronov E, et al. Among authors: kaplanov i.
Front Immunol. 2013 Jul 8;4:177. doi: 10.3389/fimmu.2013.00177. eCollection 2013.
Front Immunol. 2013.
PMID: 23847618
Free PMC article.
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Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis.
Voloshin T, Alishekevitz D, Kaneti L, Miller V, Isakov E, Kaplanov I, Voronov E, Fremder E, Benhar M, Machluf M, Apte RN, Shaked Y.
Voloshin T, et al. Among authors: kaplanov i.
Mol Cancer Ther. 2015 Jun;14(6):1385-94. doi: 10.1158/1535-7163.MCT-14-0969. Epub 2015 Apr 17.
Mol Cancer Ther. 2015.
PMID: 25887886
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The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells.
Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN.
Rider P, et al. Among authors: kaplanov i.
Front Immunol. 2012 Sep 14;3:290. doi: 10.3389/fimmu.2012.00290. eCollection 2012.
Front Immunol. 2012.
PMID: 23049530
Free PMC article.
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NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death.
Shemesh A, Kundu K, Peleg R, Yossef R, Kaplanov I, Ghosh S, Khrapunsky Y, Gershoni-Yahalom O, Rabinski T, Cerwenka A, Atlas R, Porgador A.
Shemesh A, et al. Among authors: kaplanov i.
Front Immunol. 2018 May 23;9:1114. doi: 10.3389/fimmu.2018.01114. eCollection 2018.
Front Immunol. 2018.
PMID: 29875773
Free PMC article.
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Tumor Cell-Associated IL-1α Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment.
Krishnamohan M, Kaplanov I, Maudi-Boker S, Yousef M, Machluf-Katz N, Cohen I, Elkabets M, Titus J, Bersudsky M, Apte RN, Voronov E, Braiman A.
Krishnamohan M, et al. Among authors: kaplanov i.
Int J Mol Sci. 2024 Apr 2;25(7):3950. doi: 10.3390/ijms25073950.
Int J Mol Sci. 2024.
PMID: 38612760
Free PMC article.
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