Kaplan A - Search Results

1

Multivalent Small-Molecule Pan-RAS Inhibitors.

Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, Yang WS, Tong L, Olive KP, Ferrando A, Stockwell BR. Welsch ME, et al. Among authors: kaplan a. Cell. 2017 Feb 23;168(5):878-889.e29. doi: 10.1016/j.cell.2017.02.006. Cell. 2017. PMID: 28235199 Free PMC article.

2

Therapeutic approaches to preventing cell death in Huntington disease.

Kaplan A, Stockwell BR. Kaplan A, et al. Prog Neurobiol. 2012 Dec;99(3):262-80. doi: 10.1016/j.pneurobio.2012.08.004. Epub 2012 Aug 28. Prog Neurobiol. 2012. PMID: 22967354 Free PMC article. Review.

3

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.

Kaplan A, Gaschler MM, Dunn DE, Colligan R, Brown LM, Palmer AG 3rd, Lo DC, Stockwell BR. Kaplan A, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52. doi: 10.1073/pnas.1500439112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25848045 Free PMC article.

4

Structural Elucidation of a Small Molecule Inhibitor of Protein Disulfide Isomerase.

Kaplan A, Stockwell BR. Kaplan A, et al. ACS Med Chem Lett. 2015 Jul 29;6(9):966-971. doi: 10.1021/acsmedchemlett.5b00014. eCollection 2015 Sep 10. ACS Med Chem Lett. 2015. PMID: 26500720 Free PMC article.

5

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.

Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. Shimada K, et al. Among authors: kaplan a. Nat Chem Biol. 2016 Jul;12(7):497-503. doi: 10.1038/nchembio.2079. Epub 2016 May 9. Nat Chem Biol. 2016. PMID: 27159577 Free PMC article.

6

Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.

Zhou X, Li G, Kaplan A, Gaschler MM, Zhang X, Hou Z, Jiang M, Zott R, Cremers S, Stockwell BR, Duan W. Zhou X, et al. Among authors: kaplan a. Hum Mol Genet. 2018 May 1;27(9):1545-1555. doi: 10.1093/hmg/ddy061. Hum Mol Genet. 2018. PMID: 29462355 Free PMC article.

7

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.

Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, Lo DC, Stockwell BR. Hoffstrom BG, et al. Among authors: kaplan a. Nat Chem Biol. 2010 Dec;6(12):900-6. doi: 10.1038/nchembio.467. Epub 2010 Oct 31. Nat Chem Biol. 2010. PMID: 21079601 Free PMC article.

8

Protein folding drives disulfide formation.

Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM. Kosuri P, et al. Among authors: kaplan a. Cell. 2012 Nov 9;151(4):794-806. doi: 10.1016/j.cell.2012.09.036. Cell. 2012. PMID: 23141538 Free PMC article.

9

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.

Wang C, Aleksandrov AA, Yang Z, Forouhar F, Proctor EA, Kota P, An J, Kaplan A, Khazanov N, Boël G, Stockwell BR, Senderowitz H, Dokholyan NV, Riordan JR, Brouillette CG, Hunt JF. Wang C, et al. Among authors: kaplan a. J Biol Chem. 2018 Nov 16;293(46):17685-17704. doi: 10.1074/jbc.RA117.000819. Epub 2018 Jun 14. J Biol Chem. 2018. PMID: 29903914 Free PMC article.

10

Non-Interventional Weight Changes Are Associated with Alterations in Serum Uric Acid Levels.

Weinstein S, Maor E, Bleier J, Kaplan A, Hod T, Leibowitz A, Grossman E, Shlomai G. Weinstein S, et al. Among authors: kaplan a. J Clin Med. 2024 Apr 17;13(8):2314. doi: 10.3390/jcm13082314. J Clin Med. 2024. PMID: 38673586 Free PMC article.

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